{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:21:39Z","timestamp":1791105699174,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,4,11]],"date-time":"2011-04-11T00:00:00Z","timestamp":1302480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Study objectives were to assess the efficacy, safety, and tolerability of AFQ056 in Parkinson's disease patients with levodopa\u2010induced dyskinesia. Two randomized, double\u2010blind, placebo\u2010controlled, parallel\u2010group, in\u2010patient studies for Parkinson's disease patients with moderate to severe levodopa\u2010induced dyskinesia (study 1) and severe levodopa\u2010induced dyskinesia (study 2) on stable dopaminergic therapy were performed. Patients received 25\u2013150 mg AFQ056 or placebo twice daily for 16 days (both studies). Study 2 included a 4\u2010day down\u2010titration. Primary outcomes were the Lang\u2010Fahn Activities of Daily Living Dyskinesia Scale (study 1), the modified Abnormal Involuntary Movement Scale (study 2), and the Unified Parkinson's Disease Rating Scale\u2013part III (both studies). Secondary outcomes included the Unified Parkinson's Disease Rating Scale\u2013part IV items 32\u201333. The primary analysis was change from baseline to day 16 on all outcomes. Treatment differences were assessed. Fifteen patients were randomized to AFQ056 and 16 to placebo in study 1; 14 patients were randomized to each group in study 2. AFQ056\u2010treated patients showed significant improvements in dyskinesias on day 16 versus placebo (eg, Lang\u2010Fahn Activities of Daily Living Dyskinesia Scale, <jats:italic>P<\/jats:italic> = .021 [study 1]; modified Abnormal Involuntary Movement Scale, <jats:italic>P<\/jats:italic> = .032 [study 2]). No significant changes were seen from baseline on day 16 on the Unified Parkinson's Disease Rating Scale\u2010part III in either study. Adverse events were reported in both studies, including dizziness. Serious adverse events (most commonly worsening of dyskinesias, apparently associated with stopping treatment) were reported by 4 AFQ056\u2010treated patients in study 1, and 3 patients (2 AFQ056\u2010treated patient and 1 in the placebo group) in study 2. AFQ056 showed a clinically relevant and significant antidyskinetic effect without changing the antiparkinsonian effects of dopaminergic therapy. \u00a9 2011 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.23616","type":"journal-article","created":{"date-parts":[[2011,4,11]],"date-time":"2011-04-11T10:31:38Z","timestamp":1302517898000},"page":"1243-1250","source":"Crossref","is-referenced-by-count":159,"title":["AFQ056 treatment of levodopa\u2010induced dyskinesias: Results of 2 randomized controlled 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