{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:42:40Z","timestamp":1790430160465,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,4,7]],"date-time":"2011-04-07T00:00:00Z","timestamp":1302134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with parkinsonism pose a diagnostic challenge. Parkinson's disease may be difficult to distinguish from multiple system atrophy and progressive supranuclear palsy, whereas Parkinson's disease and dementia with Lewy bodies can be difficult to distinguish from Alzheimer's disease and other dementias. A number of studies have found diminished cardiac <jats:sup>123<\/jats:sup>I\u2010metaiodobenzylguanidine uptake in Lewy body\u2013related conditions (Parkinson's disease and Lewy body dementia). In 2005, the Dementia With Lewy Bodies Consortium considered <jats:sup>123<\/jats:sup>I\u2010metaiodobenzylguanidine cardiac scintigraphy a \u201csupportive\u201d diagnostic feature, based on limited evidence. We report a meta\u2010analysis of the literature and an assessment of the utility of <jats:sup>123<\/jats:sup>I\u2010metaiodobenzylguanidine for the diagnosis of dementia with Lewy bodies and Parkinson's disease. A search was conducted of articles published between 1950 and June 2010. Forty\u2010six studies involving neuropsychiatric and movement disorders, comprising 2680 subjects, were included in the analysis. A mixed\u2010effects regression model was used to analyze the delayed mean heart\u2010to\u2010mediastinum ratio of <jats:sup>123<\/jats:sup>I\u2010metaiodobenzylguanidine uptake. <jats:sup>123<\/jats:sup>I\u2010metaiodobenzylguanidine cardiac scintigraphy sensitively detected and specifically distinguished 2 diagnostic clusters: (1) Parkinson's disease, dementia with Lewy bodies, and rapid eye movement sleep behavior disorder; and (2) normal controls and patients with Alzheimer's disease, multiple system atrophy, progressive supranuclear palsy, vascular dementia, and frontotemporal dementia. The area under the receiver operating characteristic curve was 0.987 at a cluster discriminatory heart\u2010to\u2010mediastinum ratio threshold of 1.77. This threshold yielded 94% sensitivity and 91% specificity for the discrimination of these diagnostic clusters. <jats:sup>123<\/jats:sup>I\u2010metaiodobenzylguanidine cardiac scintigraphy can accurately distinguish between 2 movement disorders, Parkinson's disease and multiple system atrophy, and between 2 common causes of dementia, Alzheimer's disease and dementia with Lewy bodies. \u00a9 2011 <jats:italic>Movement<\/jats:italic> Disorder Society<\/jats:p>","DOI":"10.1002\/mds.23659","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T05:51:15Z","timestamp":1302241875000},"page":"1218-1224","source":"Crossref","is-referenced-by-count":97,"title":["Meta\u2010analysis of <sup>123<\/sup>I\u2010MIBG cardiac scintigraphy for the diagnosis of Lewy body\u2013related disorders"],"prefix":"10.1002","volume":"26","author":[{"given":"Alisha E.","family":"King","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Mintz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald R.","family":"Royall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1998.tb05958.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10461"},{"key":"e_1_2_5_4_2","first-page":"492","article-title":"Multiple system atrophy","volume":"51","author":"Quinn N","year":"1994","journal-title":"Br J Hosp 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