{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:36:40Z","timestamp":1789997800377,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,4,25]],"date-time":"2011-04-25T00:00:00Z","timestamp":1303689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Clinical distinction between advanced essential tremor and tremulous Parkinson's disease can be difficult.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>In selected power spectra of accelerometric postural tremor recordings on the more affected side of 41 patients with essential tremor and 39 patients with tremulous Parkinson's disease being indistinguishable by tremor frequency, peak power or number of harmonic peaks, waveform asymmetry (autocorrelation decay), and mean peak power of all harmonic peaks were computed. Cutoff for essential tremor\u2013Parkinson's disease distinction was determined by receiver operating characteristics. Diagnostic yield was tested in 12 clinically unclear patients with monosymptomatic tremor, subsequently definitively diagnosed with essential tremor (n = 2) or Parkinson's disease (n = 10) by 123\u2010I FP\u2010CIT\u2013single\u2010photon emission computed tomography, fluorodopa\u2010positron emission tomography, or clinical course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>By autocorrelation decay 64%, by mean harmonic peak power 94% (Parkinson's disease &gt; essential tremor) of patients with a definite clinical diagnosis, and 11 of 12 clinically unclear patients were classified correctly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Mean harmonic power is a useful measure to separate clinically difficult cases of advanced essential tremor from tremulous Parkinson's disease. \u00a9 2011 Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.23672","type":"journal-article","created":{"date-parts":[[2011,4,25]],"date-time":"2011-04-25T20:40:41Z","timestamp":1303764041000},"page":"1548-1552","source":"Crossref","is-referenced-by-count":61,"title":["A new diagnostic test to distinguish tremulous Parkinson's disease from advanced essential tremor"],"prefix":"10.1002","volume":"26","author":[{"given":"Muthuraman","family":"Muthuraman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulnasir","family":"Hossen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Heute","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnther","family":"Deuschl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Raethjen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.8.1100"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.3.405"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.8.1554"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10125"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21505"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199603000-00002"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(01)00629-0"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2009.06.028"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.67.031903"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2010.02.005"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6107(96)00009-0"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.166084"},{"issue":"11","key":"e_1_2_6_14_2","first-page":"S2","article-title":"Diagnostic criteria for essential tremor and differential diagnosis","volume":"54","author":"Elble RJ","year":"2000","journal-title":"Neurology"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-200411000-00009"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(00)00384-9"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2004.04.006"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0712-2"},{"issue":"3","key":"e_1_2_6_19_2","first-page":"2","article-title":"Consensus statement of the Movement Disorder Society on Tremor. 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