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New genetic causes of myoclonus have been identified, and the molecular basis of several of these conditions has been discovered. It is increasingly apparent that disease of the cerebellum is particularly important in the genesis of cortical reflex myoclonus. However, the precise mechanism and origin of myoclonus in many situations remain uncertain. Effective treatment of myoclonus remains limited, and the challenge lies ahead to develop more therapeutic options. \u00a9 2011 <jats:italic>Movement<\/jats:italic> Disorder Society<\/jats:p>","DOI":"10.1002\/mds.23673","type":"journal-article","created":{"date-parts":[[2011,6,13]],"date-time":"2011-06-13T16:09:23Z","timestamp":1307981363000},"page":"1142-1148","source":"Crossref","is-referenced-by-count":40,"title":["Milestones in myoclonus"],"prefix":"10.1002","volume":"26","author":[{"given":"Hiroshi","family":"Shibasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip 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