{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T17:17:13Z","timestamp":1775495833511,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T00:00:00Z","timestamp":1305158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2011,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Carriers of fragile X mental retardation 1 repeat expansions in the premutation range (55\u2013200 CGG repeats), especially males, often develop tremor, ataxia, and parkinsonism. These neurological signs are believed to be a result of elevated levels of expanded CGG\u2010repeat fragile X mental retardation 1 mRNA. The purpose of this study was to determine the prevalence of fragile X mental retardation 1 repeat expansions in a movement disorder population comprising subjects with all types of tremor, ataxia, and parkinsonism. We screened 335 consecutive patients with tremor, ataxia, or parkinsonism and 273 controls confirmed to have no movement disorders. There was no difference in fragile X mental retardation 1 premutation size expansions in the cases compared with controls. Eleven percent of the women with Parkinson's disease had fragile X mental retardation 1 gray\u2010zone expansions compared with 4.4% of female controls (odds ratio of 3.2; 95% confidence interval, 1.2\u20138.7). Gray\u2010zone expansions in patients with other phenotypes were not overrepresented in comparison with controls. Fragile X mental retardation 1 premutation range expansions are not more common in a mixed movement disorder population compared with controls. Our results, however, suggest that fragile X mental retardation 1 gray\u2010zone alleles may be associated with Parkinson's disease in women. \u00a9 2011 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.23755","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T15:57:13Z","timestamp":1305215833000},"page":"1900-1906","source":"Crossref","is-referenced-by-count":37,"title":["<i>FMR1<\/i> gray\u2010zone alleles: Association with Parkinson's disease in women?"],"prefix":"10.1002","volume":"26","author":[{"given":"Deborah 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