{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:39:16Z","timestamp":1761007156606,"version":"build-2065373602"},"reference-count":38,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2011,10,24]],"date-time":"2011-10-24T00:00:00Z","timestamp":1319414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Given the overlap between Parkinson's disease and essential tremor, we examined genetic variants in \u03b1\u2010synuclein (<jats:italic>SNCA<\/jats:italic>) as risk determinants for essential tremor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Samples from 661 essential tremor subjects and 1316 control subjects from 4 participating North American sites were included in this study. Parkinson's disease samples (n = 427) were compared against controls. Twenty variants were selected for association analysis within the <jats:italic>SNCA<\/jats:italic> locus. Individual logistic regression analyses against essential tremor diagnosis were run for each variant and then combined using meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Our results do not show a significant association between variants in the <jats:italic>SNCA<\/jats:italic> locus and risk of essential tremor, whereas the established association of <jats:italic>SNCA<\/jats:italic> variants with Parkinson's disease risk was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Whereas genetic factors are likely to play a large role in essential tremor pathogenesis, our results do not support a role for common <jats:italic>SNCA<\/jats:italic> genetic variants in risk for essential tremor. \u00a9 2011 Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.23909","type":"journal-article","created":{"date-parts":[[2011,10,24]],"date-time":"2011-10-24T15:21:59Z","timestamp":1319469719000},"page":"2552-2556","source":"Crossref","is-referenced-by-count":12,"title":["Genetic variants of \u03b1\u2010synuclein are not associated with essential tremor"],"prefix":"10.1002","volume":"26","author":[{"given":"Owen A.","family":"Ross","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen N.","family":"Conneely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carles","family":"Vilarino\u2010Guell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra 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