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Participants were seen for a mean of 7.1 visits, with a mean follow\u2010up of 8.2 years. Subjects were evaluated using the Quantified Neurologic Examination and its Motor Impairment subscale, the Mini\u2010Mental State Examination, and the Huntington's disease Activities of Daily Living Scale. By itself, CAG repeat length showed a statistically significant but small effect on the progression of all clinical measures. Contrary to our previous expectations, controlling for age of onset increased the correlation between CAG repeat length and progression of all variables by 69% to 159%. Graphical models further supported the idea that individuals with smaller triplet expansions experience a more gradual decline. CAG repeat length becomes an important determinant of clinical prognosis when accounting for age of onset. This suggests that the aging process itself influences clinical outcomes in Huntington's disease. Inconsistent results in prior studies examining CAG repeat length and progression may indeed reflect a lack of age adjustment. \u00a9 2011 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.24024","type":"journal-article","created":{"date-parts":[[2011,12,15]],"date-time":"2011-12-15T15:02:47Z","timestamp":1323961367000},"page":"272-276","source":"Crossref","is-referenced-by-count":118,"title":["Age, CAG repeat length, and clinical progression in Huntington's disease"],"prefix":"10.1002","volume":"27","author":[{"given":"Adam","family":"Rosenblatt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brahma V.","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisa","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire S.","family":"Welsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell L.","family":"Margolis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,15]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/306234a0"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0893-387"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.10.1547"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0893-398"},{"key":"e_1_2_7_7_2","first-page":"593","article-title":"Anticipation and instability of IT\u201015 (CAG)n repeats in parent\u2010offspring pairs with Huntington disease","volume":"57","author":"Ranen NG","year":"1995","journal-title":"Am J Hum Genet."},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0893-393"},{"key":"e_1_2_7_9_2","first-page":"1202","article-title":"The likelihood of being affected with Huntington disease by a particular age, for a specific CAG size","volume":"60","author":"Brinkman RR","year":"1997","journal-title":"Am J Hum Genet."},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1995.00540320021009"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.6.1137"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.31.11.872"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.5.1000"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870100213"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.2.452"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.2.527"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000086373.32347.16"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000204230.16619.d9"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360412"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21988"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23716"},{"key":"e_1_2_7_22_2","first-page":"605","article-title":"The measurement of abnormal movement: methods developed for Huntington's disease","volume":"5","author":"Folstein SE","year":"1983","journal-title":"Neurobehav Toxicol Teratol."},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870080212"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110204"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10691"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.29.1.1"},{"key":"e_1_2_7_28_2","unstructured":"R Development Core Team (Version 2.11.1 2010\u201305\u201031). 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