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The atypical antipsychotics clozapine and quetiapine, which have affinity for 5\u2010HT<jats:sub>2A<\/jats:sub> and 5\u2010HT<jats:sub>1A<\/jats:sub> receptors, are effective against visual hallucinations in PD. 5\u2010HT<jats:sub>2A<\/jats:sub> receptors are increased in ventral visual pathways in PD patients with visual hallucinations, and we hypothesized that 5\u2010HT<jats:sub>1A<\/jats:sub> receptors were also involved in visual hallucinations in PD. Autoradiographic binding using [<jats:sup>3<\/jats:sup>H]\u2010WAY\u2010100,635 and NAN\u2010190 was performed in brain sections from 6 PD patients with visual hallucinations, 6 PD patients without visual hallucinations, and 5 age\u2010matched controls. All PD subjects had been treated with <jats:sc>L<\/jats:sc>\u2010dopa. Brain areas studied were the orbitofrontal, inferolateral temporal, and motor cortices, as well as the striatum, globus pallidus, substantia nigra, and thalamus. 5\u2010HT<jats:sub>1A<\/jats:sub>\u2010binding levels were dramatically increased in the ventral visual pathways of all PD patients compared with controls (0 vs 11 and 0 vs 100 nmol\/mg, respectively; both <jats:italic>P<\/jats:italic> &lt; .05). There was no significant difference in 5\u2010HT<jats:sub>1A<\/jats:sub>\u2010binding levels in PD patients with visual hallucinations compared with PD patients without visual hallucinations or with controls in any of the brain areas studied (<jats:italic>P<\/jats:italic> &gt; .05). Gross abnormalities in 5\u2010HT<jats:sub>1A<\/jats:sub> levels in ventral visual areas occurred in all PD patients exposed to <jats:sc>L<\/jats:sc>\u2010dopa. However, as there was no difference in 5\u2010HT<jats:sub>1A<\/jats:sub>\u2010binding levels between hallucinators and nonhallucinators, alterations in 5\u2010HT<jats:sub>1A<\/jats:sub> receptor levels may not contribute specifically to visual hallucinations in PD. However, the discrete anatomical distribution of rises to the ventral visual areas suggests some role in predisposing to visual hallucinations. \u00a9 2012 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.24964","type":"journal-article","created":{"date-parts":[[2012,3,14]],"date-time":"2012-03-14T21:02:22Z","timestamp":1331758942000},"page":"735-742","source":"Crossref","is-referenced-by-count":27,"title":["Increased levels of 5\u2010HT<sub>1A<\/sub> receptor binding in ventral visual pathways in Parkinson's disease"],"prefix":"10.1002","volume":"27","author":[{"given":"Philippe","family":"Huot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom H.","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi 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