{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:35:13Z","timestamp":1790289313233,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Several metabolic markers or conditions have been explored as possible risk or protective factors for Parkinson's disease (PD); however, results remain conflicting. We further investigated these associations using a case\u2013control study design. We used the medical records\u2013linkage system of the Rochester Epidemiology Project to identify 196 subjects who developed PD in Olmsted County, Minnesota, from 1976 through 1995. Each incident case was matched by age (\u00b11 year) and sex to a general population control. We reviewed the complete medical records of cases and controls in the medical records\u2013linkage system to abstract information about body mass index (BMI), cholesterol level, hypertension, and diabetes mellitus preceding the onset of PD (or the index year). There were no significant differences between cases and controls for the metabolic markers or conditions investigated. No significant associations were found using 2 cutoffs for BMI level (BMI \u2265 25 or BMI \u2265 30 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) and 3 cutoffs for cholesterol levels (&gt;200, &gt;250, or &gt;300 mg\/dL). Neither a diagnosis of hypertension or the documented use of antihypertensive medications was significantly associated with the subsequent risk of PD (odds ratio [OR], 1.00; 95% confidence interval [CI], 0.65\u20131.54;\n                    <jats:italic>P<\/jats:italic>\n                    = .99) nor was a diagnosis of diabetes mellitus or the use of glucose\u2010lowering medications (OR, 0.77; 95% CI, 0.37\u20131.57;\n                    <jats:italic>P<\/jats:italic>\n                    = .47). Our study, based on historical information from a records\u2010linkage system, does not support an association between BMI, cholesterol level, hypertension, or diabetes mellitus with later development of PD. \u00a9 2012\n                    <jats:italic>Movement<\/jats:italic>\n                    Disorder Society\n                  <\/jats:p>","DOI":"10.1002\/mds.25016","type":"journal-article","created":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T13:24:14Z","timestamp":1338557054000},"page":"974-979","source":"Crossref","is-referenced-by-count":54,"title":["Metabolic markers or conditions preceding Parkinson's disease: A case\u2010control study"],"prefix":"10.1002","volume":"27","author":[{"given":"Rodolfo","family":"Savica","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon R.","family":"Grossardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Eric","family":"Ahlskog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter A.","family":"Rocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3283050461"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.02.013"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.4065\/71.3.266"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq482"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.6.1214"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200203000-00010"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(79)90012-2"},{"key":"e_1_2_7_9_2","unstructured":"NIH Roadmap for Medical Research: Roadmap Initiatives. 2011 National Institutes of Health"},{"key":"e_1_2_7_10_2","unstructured":"2010 American Heart Association American Heart Association TX Dallas What Your Cholesterol Levels Mean"},{"key":"e_1_2_7_11_2","first-page":"5","article-title":"Statistical Methods in Cancer Research. Volume I: The analysis of case\u2010control studies","author":"Breslow NE","year":"1980","journal-title":"IARC Sci Publ."},{"key":"e_1_2_7_12_2","volume-title":"Epidemiology: Beyond the Basics","author":"Szklo M","year":"2000"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.1.91"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.9.1350"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.7.1051"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000247052.18422.e5"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh059"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23855"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj283"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000312511.62699.a8"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000271883.45010.8a"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2005.09.004"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2010.03.002"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21937"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-2011"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2009.02.013"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.25016","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.25016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:53:48Z","timestamp":1760964828000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.25016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1002\/mds.25016"],"URL":"https:\/\/doi.org\/10.1002\/mds.25016","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}