{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:55:18Z","timestamp":1791280518655,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,8,7]],"date-time":"2012-08-07T00:00:00Z","timestamp":1344297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2012,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Writer's cramp is a task\u2010specific form of dystonia with symptoms characterized by abnormal movements and postures of the hand and arm evident only during writing. Its pathophysiology has been related to faulty sensorimotor integration, abnormal sensory processing, and impaired motor planning. Its symptoms might appear when the computational load of writing pushes a tonically altered circuit outside its operational range. Using resting\u2010state fMRI, we tested whether writer's cramp patients have altered intrinsic functional connectivity in the premotor\u2013parietal circuit. Sixteen patients with right\u2010sided writer's cramp and 19 control subjects were studied. We show that writer's cramp patients have reduced connectivity between the superior parietal lobule and a dorsal precentral region that controls writing movements. This difference between patients and controls occurred in the absence of writing and only in the hemisphere contralateral to the affected hand. This finding adds a novel element to the pathophysiological substrate for writer's cramp, namely, task\u2010independent alterations within a writing\u2010related circuit. \u00a9 2012 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.25029","type":"journal-article","created":{"date-parts":[[2012,8,7]],"date-time":"2012-08-07T15:51:15Z","timestamp":1344354675000},"page":"1425-1431","source":"Crossref","is-referenced-by-count":73,"title":["Reduced parietal connectivity with a premotor writing area in writer's cramp"],"prefix":"10.1002","volume":"27","author":[{"given":"Cath\u00e9rine C.S.","family":"Delnooz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick C.","family":"Helmich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Toni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart P.C.","family":"van de Warrenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,7]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humov.2006.05.004"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22814"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2009.03.004"},{"key":"e_1_2_7_5_2","article-title":"Writer's cramp: Increased dorsal premotor activity during intended writing","author":"Delnooz CC","year":"2011","journal-title":"Hum Brain Mapp."},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00088-0"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3282f1c720"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4499-09.2010"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3923-07.2007"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.11.033"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/2245"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.20.1.25"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-002-1078-9"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000196"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812686106"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.1.73"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.61.2.172"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp178"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.02.021"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012372560-8\/50002-4"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.12.005"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.12.034"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21250"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0135058100"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00801.x"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002210000660"},{"key":"e_1_2_7_28_2","article-title":"Topographic maps within Brodmann's area 5 of Macaque monkeys","author":"Seelke AM","year":"2011","journal-title":"Cereb Cortex."},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.3.537"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23675"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21804"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2011.02.010"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/105.3.461"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.08.004"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000266591.49624.1a"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg216"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.02.048"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.037"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.25029","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.25029","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.25029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:33:59Z","timestamp":1760960039000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.25029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,7]]},"references-count":37,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,9,15]]}},"alternative-id":["10.1002\/mds.25029"],"URL":"https:\/\/doi.org\/10.1002\/mds.25029","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,7]]}}}