{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:05:37Z","timestamp":1790417137318,"version":"4.1.0"},"reference-count":79,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T00:00:00Z","timestamp":1341532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mild cognitive impairment is increasingly recognized as a construct in Parkinson's disease (PD) and occurs in about 25% of nondemented PD patients. Although executive dysfunction is the most frequent type of cognitive deficit in PD, the cognitive phenotype of PD mild cognitive impairment (PD\u2010MCI) is broad. PD\u2010MCI subtypes are represented by amnestic and nonamnestic domain impairment as well as single\u2010 and multiple\u2010domain impairment. However, it is unclear whether patients with different PD\u2010MCI subtypes also differ in other clinical characteristics in addition to cognitive profile. We studied 128 PD\u2010MCI subjects at our Movement Disorders center, comparing clinical, motor, and behavioral characteristics across the PD\u2010MCI subtypes. We found varying proportions of impairment subtypes: nonamnestic single domain, 47.7%; amnestic multiple domain, 24.2%; amnestic single domain, 18.8%; and nonamnestic multiple domain, 9.5%. Attentional\/executive functioning and visuospatial abilities were the most frequently impaired domains. PD\u2010MCI subtypes differed in their motor features, with nonamnestic multiple\u2010domain PD\u2010MCI subjects showing particularly pronounced problems with postural instability and gait. Differences among PD\u2010MCI subtypes in age, PD duration, medication use, mood or behavioral disturbances, and vascular disease were not significant. Thus, in addition to differing cognitive profiles, PD\u2010MCI subtypes differed in motor phenotype and severity but not in mood, behavioral, or vascular comorbidities. Greater postural instability and gait disturbances in the nonamnestic multiple\u2010domain subtype emphasize shared nondopaminergic neural substrates of gait and cognition in PD. Furthermore, increased burden of cognitive dysfunction, rather than type of cognitive deficit, may be associated with greater motor impairment in PD\u2010MCI. \u00a9 2012 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.25062","type":"journal-article","created":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T10:58:28Z","timestamp":1341572308000},"page":"1129-1136","source":"Crossref","is-referenced-by-count":93,"title":["Clinical differences among mild cognitive impairment subtypes in Parkinson's disease"],"prefix":"10.1002","volume":"27","author":[{"given":"Jennifer 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