{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:01:12Z","timestamp":1762866072258,"version":"build-2065373602"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T00:00:00Z","timestamp":1347494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"United States Department of the Army","award":["DAMD17-98-1-8621"],"award-info":[{"award-number":["DAMD17-98-1-8621"]}]},{"name":"National Institutes of Health, National Institute of Neurological Disorders and Stroke","award":["5 R01 NS041265"],"award-info":[{"award-number":["5 R01 NS041265"]}]},{"name":"National Institute on Aging Grants","award":["1 U01 AG19349","5 R01 AG017155"],"award-info":[{"award-number":["1 U01 AG19349","5 R01 AG017155"]}]},{"name":"Office of Research and Development, Medical Research Service Department of Veterans Affairs"},{"name":"Intramural Research Program of the NIH, National Institute on Aging"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2012,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although organochlorines have been reported more frequently in Parkinson's disease (PD) brains than in controls, the association with brain Lewy pathology is unknown. Honolulu\u2010Asia Aging Study (HAAS) participants, exposed to organochlorines from a variety of sources during midlife, represent a population well suited to determining the relationship of brain organochlorines with Lewy pathology in decedents from the longitudinal HAAS. The study design included the measurement of 21 organochlorine levels in frozen occipital lobe samples from HAAS decedents. Alpha\u2010synuclein immunostaining performed on 225 brains was used to identify Lewy bodies and Lewy neurites. With the potential for spurious associations to appear between Lewy pathology and 17 organochlorine compounds found in at least 1 brain, initial assessments identified heptachlor epoxide isomer b, methoxychlor, and benzene hexachloride b as being most important. The prevalence of Lewy pathology was 75% (6 of 8) among brains with any 2 of the 3 compounds, 48.8% (79 of 162) among those with 1, and 32.7% (18 of 55) for those with neither (<jats:italic>P<\/jats:italic> = .007 test for trend). Although findings persisted after removing cases with PD and dementia with Lewy bodies and after adjustment for age at death, body mass index, pack\u2010years of cigarette smoking, and coffee intake (<jats:italic>P<\/jats:italic> = .013), the results were insignificant when correcting for multiple testing. Although consistent with earlier accounts of an association between organochlorines and clinical PD, associations with Lewy pathology warrant further study. \u00a9 2012 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.25144","type":"journal-article","created":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T08:33:41Z","timestamp":1347525221000},"page":"1418-1424","source":"Crossref","is-referenced-by-count":10,"title":["Brain organochlorines and Lewy pathology: The Honolulu\u2010Asia aging study"],"prefix":"10.1002","volume":"27","author":[{"given":"G. 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