{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:33Z","timestamp":1786978173832,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,10,31]],"date-time":"2012-10-31T00:00:00Z","timestamp":1351641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>Pallidonigroluysian atrophy is a rare neurodegenerative disease characterized by degeneration of the globus pallidus, substantia nigra, and subthalamic nucleus. Few studies have comprehensively documented the clinical and pathological features of pallidonigroluysian atrophy. A systematic review of all published cases of pallidonigroluysian atrophy in English since 1970 was performed. We also report a new case of pallidonigroluysian atrophy. Twenty\u2010five cases of pathologically proven pallidonigroluysian atrophy were reviewed, 24 from the literature and 1 of our own. Average age of onset was 54.3 \u00b1 14.3 years, and average duration of disease was 7.9 \u00b1 5.8 years. The most common first symptom was gait or balance disturbance. Patients had a diversity of movement disorders, including chorea in 5 cases (20%). Nine cases (36%) had coexistent motor neuron disease. Almost all cases had gliosis, and many cases had iron\u2010positive pigments in the pallidonigroluysian system. Tauopathy was absent to rare in this region. Widespread tau\u2010negative, p62\u2010positive glial inclusions, described in 1 previous case, were also present in our patient. As pallidonigroluysian atrophy has a diversity of clinical presentations, it is best defined neuropathologically. The relative lack of tauopathy and the presence of p62\u2010positive glial inclusions or iron\u2010positive pigments in the pallidonigroluysian region may help to distinguish pallidonigroluysian atrophy from similar disease entities. \u00a9 2012 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.25232","type":"journal-article","created":{"date-parts":[[2012,10,31]],"date-time":"2012-10-31T21:17:49Z","timestamp":1351718269000},"page":"274-281","source":"Crossref","is-referenced-by-count":14,"title":["Clinicopathological review of pallidonigroluysian atrophy"],"prefix":"10.1002","volume":"28","author":[{"given":"Janice C.","family":"Wong","sequence":"first","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa J.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Medicine (Neurology) University of Toronto Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease Toronto Western Hospital Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony E.","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Medicine (Neurology) University of Toronto Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease Toronto Western Hospital Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili\u2010Naz","family":"Hazrati","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,31]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"107","article-title":"[Atrophy of the globus pallidus, substancia nigra, and nucleus subthalamicus. 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