{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T05:38:36Z","timestamp":1774417116236,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T00:00:00Z","timestamp":1358294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Multiple system atrophy of the cerebellar type is a sporadic neurodegenerative disorder of the central nervous system. We hypothesized that the white matter degeneration of the cerebellum and pons in this disease may cause a breakdown of cerebellar structural networks and further reduce the network efficiency of cerebellar\u2010connected cerebral regions. Diffusion tensor tractography was used to construct the structural networks of 19 cerebellar\u2010type multiple system atrophy patients, who were compared with 19 age\u2010 and sex\u2010matched controls. Graph theory was used to assess the small\u2010world properties and topological organization of structure networks in both the control and patient groups. Our results showed that the cerebellar\u2010type multiple system atrophy patients exhibited altered small\u2010world architecture with significantly increased characteristic shortest path lengths and decreased clustering coefficients. We also found that white matter degeneration in the cerebellum was characterized by reductions in network strength (number and integrity of fiber connections) of the cerebellar regions, which further induced extensively decreased network efficiency for numerous cerebral regions. Finally, we found that the reductions in nodal efficiency of the cerebellar lobules and bilateral sensorimotor, prefrontal, and basal ganglia regions negatively correlated with the severity of ataxia for the cerebellar\u2010type multiple system atrophy patients. This study demonstrates for the first time that the brains of cerebellar\u2010type multiple system atrophy patients exhibit disrupted topological organization of white matter structural networks. Thus, this study provides structural evidence of the relationship between abnormalities of white matter integrity and network efficiency that occurs in cerebellar\u2010type multiple system atrophy. \u00a9 2013 <jats:italic>Movement<\/jats:italic> Disorder Society<\/jats:p>","DOI":"10.1002\/mds.25314","type":"journal-article","created":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T12:03:49Z","timestamp":1358337829000},"page":"362-369","source":"Crossref","is-referenced-by-count":26,"title":["Disrupted cerebellar connectivity reduces whole\u2010brain network efficiency in multiple system atrophy"],"prefix":"10.1002","volume":"28","author":[{"given":"Chia\u2010Feng","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Biomedical Imaging and Radiological Sciences National Yang\u2010Ming University Taipei Taiwan, ROC"},{"name":"Integrated Brain Research Laboratory Department of Medical Research and Education Taipei Veterans General Hospital Taipei Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing\u2010Wen","family":"Soong","sequence":"additional","affiliation":[{"name":"Department of Neurology National Yang\u2010Ming University School of Medicine Taipei Taiwan, Republic of China"},{"name":"Department of Neurology the Neurological Institute Taipei Veterans General Hospital Taipei Taiwan, Republic of China"},{"name":"Brain Research Center National Yang\u2010Ming University Taipei Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiu\u2010Mei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology Taipei Veterans General Hospital Taipei Taiwan, Republic of China"},{"name":"Department of Radiology School of Medicine National Yang\u2010Ming University Taipei Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Biomedical Imaging and Radiological Sciences National Yang\u2010Ming University Taipei Taiwan, ROC"},{"name":"Integrated Brain Research Laboratory Department of Medical Research and Education Taipei Veterans General Hospital Taipei Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po\u2010Shan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology National Yang\u2010Ming University School of Medicine Taipei Taiwan, Republic of China"},{"name":"Brain Research Center National Yang\u2010Ming University Taipei Taiwan, Republic of China"},{"name":"The Neurological Institute Taipei Municipal Gan\u2010Dau Hospital Taipei Taiwan, Republic of China"},{"name":"Institute of Brain Science National Yang\u2010Ming University Taipei Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Te","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Imaging 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