{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:58:09Z","timestamp":1791035889307,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T00:00:00Z","timestamp":1360713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Secondary dystonia encompasses a heterogeneous group with different etiologies. Cerebral palsy is the most common cause. Pharmacological treatment is often unsatisfactory. There are only limited data on the therapeutic outcomes of deep brain stimulation in dyskinetic cerebral palsy. The published literature regarding deep brain stimulation and secondary dystonia was reviewed in a meta\u2010analysis to reevaluate the effect on cerebral palsy. The Burke\u2010Fahn\u2010Marsden Dystonia Rating Scale movement score was chosen as the primary outcome measure. Outcome over time was evaluated and summarized by mixed\u2010model repeated\u2010measures analysis, paired Student <jats:italic>t<\/jats:italic> test, and Pearson's correlation coefficient. Twenty articles comprising 68 patients with cerebral palsy undergoing deep brain stimulation assessed by the Burke\u2010Fahn\u2010Marsden Dystonia Rating Scale were identified. Most articles were case reports reflecting great variability in the score and duration of follow\u2010up. The mean Burke\u2010Fahn\u2010Marsden Dystonia Rating Scale movement score was 64.94 \u00b1 25.40 preoperatively and dropped to 50.5 \u00b1 26.77 postoperatively, with a mean improvement of 23.6% (<jats:italic>P<\/jats:italic> &lt; .001) at a median follow\u2010up of 12 months. The mean Burke\u2010Fahn\u2010Marsden Dystonia Rating Scale disability score was 18.54 \u00b1 6.15 preoperatively and 16.83 \u00b1 6.42 postoperatively, with a mean improvement of 9.2% (<jats:italic>P<\/jats:italic> &lt; .001). There was a significant negative correlation between severity of dystonia and clinical outcome (<jats:italic>P<\/jats:italic> &lt; .05). Deep brain stimulation can be an effective treatment option for dyskinetic cerebral palsy. In view of the heterogeneous data, a prospective study with a large cohort of patients in a standardized setting with a multidisciplinary approach would be helpful in further evaluating the role of deep brain stimulation in cerebral palsy. \u00a9 2013 <jats:italic>Movement<\/jats:italic> Disorder Society<\/jats:p>","DOI":"10.1002\/mds.25339","type":"journal-article","created":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T11:43:51Z","timestamp":1360755831000},"page":"647-654","source":"Crossref","is-referenced-by-count":147,"title":["Effects of deep brain stimulation in dyskinetic cerebral palsy: A meta\u2010analysis"],"prefix":"10.1002","volume":"28","author":[{"given":"Anne","family":"Koy","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital Cologne  Germany"},{"name":"Department of General Pediatrics and Neonatology University Children's Hospital D\u00fcsseldorf  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hellmich","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics, Informatics and Epidemiology University of Cologne  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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