{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T01:45:11Z","timestamp":1770342311644,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T00:00:00Z","timestamp":1360540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pallidal deep brain stimulation (<jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content>) is an established treatment for disabling, medication\u2010refractory generalized dystonia. Patients typically regress to their preoperative baseline when stimulation is discontinued.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Presented are case reports of 2 dystonia patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two patients with primary generalized dystonia (1 with the <jats:styled-content style=\"fixed-case\"><jats:italic>DYT1<\/jats:italic><\/jats:styled-content> mutation) who were treated successfully with bilateral pallidal <jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content> for periods of 18 months and 5 years retained motor benefit for several months after inadvertent interruption of stimulation. Stimulation was interrupted unilaterally for 3 and 7 months and bilaterally for 2 days and 2 months, respectively. Symptoms of dystonia returned only partially during the period of therapy interruption and rapidly and completely resolved after resuming stimulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We report unexpected and prolonged retention of motor benefits despite transient cessation of pallidal <jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content> in 2 dystonia patients. Factors that appear to differentiate these individuals are young age, short duration of disease, and chronic <jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content> therapy with relatively low energy of stimulation. \u00a9 2013 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.25353","type":"journal-article","created":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T11:25:36Z","timestamp":1360581936000},"page":"1431-1434","source":"Crossref","is-referenced-by-count":30,"title":["Sustained relief of generalized dystonia despite prolonged interruption of deep brain stimulation"],"prefix":"10.1002","volume":"28","author":[{"given":"Tyler","family":"Cheung","sequence":"first","affiliation":[{"name":"Department of Neurology Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital of the University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Rudolph","sequence":"additional","affiliation":[{"name":"Department of Neurology Cleveland Clinic Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron L.","family":"Alterman","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Beth Israel Deaconess Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Tagliati","sequence":"additional","affiliation":[{"name":"Department of Neurology Cedars\u2010Sinai Medical Center Los Angeles California 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