{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:09:12Z","timestamp":1792019352677,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,11]],"date-time":"2013-03-11T00:00:00Z","timestamp":1362960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The objective of this study was to validate disease\u2010related metabolic brain patterns for Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 20 patients with Parkinson's disease, 21 with multiple system atrophy, and 17 with progressive supranuclear palsy, all of whom had undergone a clinically motivated [18F]\u2010fluoro\u2010deoxyglucose positron emission tomography scan at an early stage of their disease. At a follow\u2010up time after the scan of 2\u20134 years, a clinical diagnosis was made according to established clinical research criteria. Patient groups were compared with 18 healthy controls using a multivariate covariance image analysis technique called scaled subprofile model\/principal component analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Disease\u2010related metabolic brain patterns for these parkinsonian disorders were identified. Validation showed that these patterns were highly discriminative of the 3 disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early diagnosis of parkinsonian disorders is feasible when the expression of disease\u2010related metabolic brain patterns is quantified at a single\u2010subject level. \u00a9 2013 <jats:italic>Movement<\/jats:italic> Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.25361","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T04:52:12Z","timestamp":1363150332000},"page":"547-551","source":"Crossref","is-referenced-by-count":109,"title":["Validation of parkinsonian disease\u2010related metabolic brain patterns"],"prefix":"10.1002","volume":"28","author":[{"given":"Laura K.","family":"Teune","sequence":"first","affiliation":[{"name":"Department of Neurology University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remco J.","family":"Renken","sequence":"additional","affiliation":[{"name":"NeuroImaging Center University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Mudali","sequence":"additional","affiliation":[{"name":"Johann Bernoulli Institute for Mathematics and Computer Science University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bauke M.","family":"De Jong","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudi A.","family":"Dierckx","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging University Medical Center Groningen Groningen The 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