{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:13:57Z","timestamp":1780107237749,"version":"3.54.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,3,11]],"date-time":"2013-03-11T00:00:00Z","timestamp":1362960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The pathogenesis of essential tremor is poorly understood. Historically, it has been hypothesized that the inferior olivary nucleus plays an important role in the generation of tremor in essential tremor, yet a detailed, controlled, anatomic\u2010pathological study of that brain region has yet to be conducted. A detailed postmortem study was undertaken of the microscopic changes in the inferior olivary nucleus of 14 essential tremor cases versus 15 age\u2010matched controls at the Essential Tremor Centralized Brain Repository. A series of metrics was used to quantify microscopic neuronal and glial changes in the inferior olivary nucleus and its input and output tracts. Olivary linear neuronal density also was assessed. Cases and controls did not differ from one another with respect to any of the assessed metrics (<jats:italic>P<\/jats:italic> values ranged from 0.23 to 1.0). Olivary linear neuronal density also was similar in cases and controls (<jats:italic>P<\/jats:italic>\u2009=\u20090.62). Paddle\u2010shaped neurons, a morphologic shape change in olivary neurons, which, to our knowledge, have not been previously recognized, occurred to an equal degree in essential tremor cases and controls (<jats:italic>P<\/jats:italic>\u2009=\u20090.89) and were correlated with several markers of neuronal loss and gliosis. A systematic postmortem study of the microscopic changes in the inferior olivary nucleus did not detect any differences between cases and controls. These data, along with positron emission tomography data, which have failed to identify any metabolic abnormality of the olive, indicate that, if the olive is involved in essential tremor, then there is no clearly identifiable structural or metabolic correlate. \u00a9 2013 <jats:italic>Movement<\/jats:italic> Disorder Society<\/jats:p>","DOI":"10.1002\/mds.25400","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T04:30:44Z","timestamp":1363149044000},"page":"779-786","source":"Crossref","is-referenced-by-count":57,"title":["The inferior olivary nucleus: A postmortem study of essential tremor cases versus controls"],"prefix":"10.1002","volume":"28","author":[{"given":"Elan D.","family":"Louis","sequence":"first","affiliation":[{"name":"G. H. Sergievsky Center College of Physicians and Surgeons Columbia University New York New York USA"},{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain College of Physicians and Surgeons Columbia University New York New York USA"},{"name":"Department of Neurology College of Physicians and Surgeons Columbia University New York New York USA"},{"name":"Department of Epidemiology Mailman School of Public Health Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Babij","sequence":"additional","affiliation":[{"name":"G. H. Sergievsky Center College of Physicians and Surgeons Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etty","family":"Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Medical Center and the New York Presbyterian Hospital New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Paul G.","family":"Vonsattel","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain College of Physicians and Surgeons Columbia University New York New York USA"},{"name":"Department of Pathology and Cell Biology Columbia University Medical Center and the New York Presbyterian Hospital New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis L.","family":"Faust","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell 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