{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:06:50Z","timestamp":1791036410022,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T00:00:00Z","timestamp":1363132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Essential tremor (ET) follows an autosomal dominant type of inheritance in the majority of patients, yet its genetic basis has not been identified. Its exact origin is still elusive, but coherence measurements between electromyography tremor bursts and electroencephalography unequivocally demonstrate a correlation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We tested these measurements in 37 healthy first\u2010degree relatives (children) of patients with essential tremor (ET) and a group of 37 age\u2010matched and sex\u2010matched controls. Pooled coherence spectra of the maximally coherent electroencephalogram electrodes were computed for ET relatives and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The maximal coherence and its frequency were significantly higher in ET relatives than in controls during the pinch grip task and during slow hand movements. Electromyography amplitude (root\u2010mean\u2010square) was slightly but significantly greater in ET relatives, whereas 2\u2010Hz to 40\u2010Hz power and spectral peak frequency were not different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presymptomatic alteration in corticomuscular interaction may reflect a role of genetic factors. \u00a9 2013 <jats:italic>Movement<\/jats:italic> Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.25425","type":"journal-article","created":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T06:54:13Z","timestamp":1363244053000},"page":"679-682","source":"Crossref","is-referenced-by-count":5,"title":["Corticomuscular coherence in asymptomatic first\u2010degree relatives of patients with essential tremor"],"prefix":"10.1002","volume":"28","author":[{"given":"Jan","family":"Raethjen","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital Schleswig Holstein Campus Kiel 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