{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:46:28Z","timestamp":1792129588532,"version":"4.4.0"},"reference-count":55,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,4,2]],"date-time":"2013-04-02T00:00:00Z","timestamp":1364860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Pathological gambling develops in up to 8% of patients with Parkinson's disease. Although the pathophysiology of gambling remains unclear, several findings argue for a dysfunction in the basal ganglia circuits. To clarify the role of the subthalamic nucleus in pathological gambling, we studied its activity during economics decisions. We analyzed local field potentials recorded from deep brain stimulation electrodes in the subthalamic nucleus while parkinsonian patients with (n\u2009=\u20098) and without (n\u2009=\u20099) pathological gambling engaged in an economics decision\u2010making task comprising conflictual trials (involving possible risk\u2010taking) and non conflictual trials. In all parkinsonian patients, subthalamic low frequencies (2\u201312 Hz) increased during economics decisions. Whereas, in patients without gambling, low\u2010frequency oscillations exhibited a similar pattern during conflictual and non conflictual stimuli, in those with gambling, low\u2010frequency activity increased significantly more during conflictual than during non conflictual stimuli. The specific low\u2010frequency oscillatory pattern recorded in patients with Parkinson's disease who gamble could reflect a subthalamic dysfunction that makes their decisional threshold highly sensitive to risky options. When parkinsonian patients process stimuli related to an economics task, low\u2010frequency subthalamic activity increases. This task\u2010related change suggests that the cognitive\u2010affective system that drives economics decisional processes includes the subthalamic nucleus. The specific subthalamic neuronal activity during conflictual decisions in patients with pathological gambling supports the idea that the subthalamic nucleus is involved in behavioral strategies and in the pathophysiology of gambling. \u00a9 2013 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.25427","type":"journal-article","created":{"date-parts":[[2013,4,2]],"date-time":"2013-04-02T09:14:08Z","timestamp":1364894048000},"page":"1644-1652","source":"Crossref","is-referenced-by-count":64,"title":["Pathological gambling in Parkinson's disease: Subthalamic oscillations during economics decisions"],"prefix":"10.1002","volume":"28","author":[{"given":"Manuela","family":"Rosa","sequence":"first","affiliation":[{"name":"Centro Clinico per la Neurostimolazione, le Neurotecnologie ed i Disordini del Movimento Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico Milan 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