{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:51:24Z","timestamp":1791165084479,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T00:00:00Z","timestamp":1368489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Recently, the American Academy of Neurology published an evidence\u2010based guideline for the pharmacological treatment of chorea in Huntington's disease. Although the progress in medical care because of the implementation of criteria of evidence\u2010based medicine is undisputed, the guideline classifies the level of evidence for drugs to reduce chorea based on anchors in the Unified Huntington's Disease Rating Scale\u2010Total Motor Score chorea sum score, which were chosen arbitrarily and do not reflect validated or generally accepted levels of clinical relevance. Thus, the guideline faces several serious limitations and delivers clinical recommendations that do not represent current clinical practice; these are reviewed in detail, and arguments are presented why these recommendations should not be followed. To remedy the lack of evidence\u2010based recommendations and provide guidance to a pragmatic symptomatic therapy of chorea in HD, a flow\u2010chart pathway that follows currently established clinical standards based on expert opinion is presented. \u00a9 2013\n                    <jats:italic>Movement<\/jats:italic>\n                    Disorder Society\n                  <\/jats:p>","DOI":"10.1002\/mds.25500","type":"journal-article","created":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T09:31:21Z","timestamp":1368523881000},"page":"1030-1033","source":"Crossref","is-referenced-by-count":56,"title":["Pharmacological treatment of chorea in Huntington's disease\u2013good clinical practice versus evidence\u2010based guideline"],"prefix":"10.1002","volume":"28","author":[{"given":"Ralf","family":"Reilmann","sequence":"first","affiliation":[{"name":"Huntington Group, Department of Neurology University Clinic Muenster, Westfaelische Wilhelms University of Muenster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,14]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318263c443"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110204"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617711000725"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/currents.RRN1260"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000096019.71649.2B"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21181"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182885eb3"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000198586.85250.13"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.5.694"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.7.996"},{"issue":"3","key":"e_1_2_3_12_1","first-page":"CD006456","article-title":"Therapeutic interventions for symptomatic treatment in Huntington's disease [serial online]","author":"Mestre T","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100720200081"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000068165.07883.64"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.63.3.597"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23953"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.25500","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.25500","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.25500","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:16:37Z","timestamp":1760966197000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.25500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,14]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1002\/mds.25500"],"URL":"https:\/\/doi.org\/10.1002\/mds.25500","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,14]]}}}