{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:27:48Z","timestamp":1789990068478,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T00:00:00Z","timestamp":1372118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Movement disorders are a prominent feature of glucose transporter\u20101 (GLUT1) deficiency syndrome (GLUT1DS). First\u2010choice treatment is a ketogenic diet, but compliance is poor. We have investigated the effect of the modified Atkins diet as an alternative treatment for movement disorders in GLUT1DS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four patients with GLUT1DS ages 15 to 30 years who had movement disorders as the most prominent feature were prospectively evaluated after initiation of the modified Atkins diet. Movement disorders included dystonia, ataxia, myoclonus, and spasticity, either continuous or paroxysmal, triggered by action or exercise. Duration of treatment ranged from 3 months to 16 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients reached mild to moderate ketosis and experienced remarkable improvement in the frequency and severity of paroxysmal movement disorders. Cognitive function also improved subjectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The modified Atkins diet is an effective and feasible alternative to the ketogenic diet for the treatment of GLUT1DS\u2010related paroxysmal movement disorders in adolescence and adulthood. \u00a9 2013 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.25515","type":"journal-article","created":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T09:29:49Z","timestamp":1372152589000},"page":"1439-1442","source":"Crossref","is-referenced-by-count":51,"title":["Movement disorders in GLUT1 deficiency syndrome respond to the modified Atkins diet"],"prefix":"10.1002","volume":"28","author":[{"given":"Wilhelmina G.","family":"Leen","sequence":"first","affiliation":[{"name":"Department of Neurology Radboud University Medical Centre, Donders Institute for Brain, Cognition, and Behaviour Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"Mewasingh","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology Imperial College Healthcare National Health Service Trust London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel M.","family":"Verbeek","sequence":"additional","affiliation":[{"name":"Department of Neurology Radboud University Medical Centre, Donders Institute for Brain, Cognition, and Behaviour Nijmegen the Netherlands"},{"name":"Department of Laboratory Medicine Radboud University Medical Centre Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik\u2010Jan","family":"Kamsteeg","sequence":"additional","affiliation":[{"name":"Department of Genetics Radboud University Medical Centre  the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart P.","family":"van de Warrenburg","sequence":"additional","affiliation":[{"name":"Department of Neurology Radboud University Medical Centre, Donders Institute for Brain, Cognition, and Behaviour Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel A.","family":"Willemsen","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology Radboud University Medical Centre, Donders Institute for Brain, Cognition, and Behaviour Nijmegen the 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