{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T14:48:03Z","timestamp":1788360483454,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T00:00:00Z","timestamp":1373500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Lewy bodies have been described in the locus coeruleus of some patients with essential tremor (ET), and this brainstem nucleus plays an important role in sleep cycle regulation. Despite this, no studies have investigated the relationship between daily sleep duration and the risk of ET. We determined whether baseline daily sleep duration was associated with an increased risk of incident ET. In this prospective, population\u2010based study of individuals\u2009&gt;\u200965 years of age (the Neurological Disorders in Central Spain [NEDICES] cohort), participants were evaluated at baseline and 3 years later. At baseline, participants indicated their daily sleep duration as the sum of nighttime sleep and daytime napping. The average daily total sleep duration was grouped into four categories:\u2009\u2264\u20095 hours (short sleepers), 6 hours, 7 to 8 hours (reference), and\u2009\u2265\u20099 hours (long sleepers) hours. In total, 3,303 participants had a median duration of follow\u2010up of 3.3 years. There were 76 incident ET cases at follow\u2010up. The relative risks for short sleepers and for long sleepers were 2.25 (95% confidence interval [CI], 1.21\u20104.16; <jats:italic>P<\/jats:italic>\u2009=\u20090.01) and 0.74 (95% CI, 0.41\u20101.32; <jats:italic>P<\/jats:italic>\u2009=\u20090.31), respectively. After adjustment for potential confounders, including age, sex, educational level, current smoker, current drinker, and depressive symptoms or antidepressant use, the risk remained significantly increased for short sleepers (relative risk, 1.95; 95% CI, 1.03\u20103.70; <jats:italic>P<\/jats:italic>\u2009=\u20090.04]). The results indicated that short daily sleep duration may be a pre\u2010motor marker for ET. Additional prospective studies are needed to confirm these results, and the biological basis for this association merits additional investigation. \u00a9 2013 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.25590","type":"journal-article","created":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T11:10:46Z","timestamp":1373541046000},"page":"1700-1707","source":"Crossref","is-referenced-by-count":30,"title":["Short sleep duration heralds essential tremor: A prospective, population\u2010based study"],"prefix":"10.1002","volume":"28","author":[{"given":"Juli\u00e1n","family":"Benito\u2010Le\u00f3n","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital \u201c12 de Octubre\u201d Madrid Spain"},{"name":"Department of Medicine, Faculty of Medicine Complutense University Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elan D.","family":"Louis","sequence":"additional","affiliation":[{"name":"G. 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Sergievsky Center, College of Physicians and Surgeons Columbia University, New York New York USA"},{"name":"Department of Neurology, College of Physicians and Surgeons Columbia University, New York New York USA"},{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons Columbia University, New York New York USA"},{"name":"Department of Epidemiology Mailman School of Public Health Columbia University, New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9lix","family":"Bermejo\u2010Pareja","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital \u201c12 de Octubre\u201d Madrid Spain"},{"name":"Department of Medicine, Faculty of Medicine Complutense University Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10376"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000161852.70374.01"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000195692"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000323572"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.09.001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22124"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000279339.87987.d7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60544-3"},{"key":"e_1_2_7_10_1","first-page":"417","article-title":"Update on essential tremor","volume":"102","author":"Benito\u2010Le\u00f3n J","year":"2011","journal-title":"Minerva Med"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2005.04.007"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.05.004"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm266"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.08.037"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.6.1004"},{"issue":"5","key":"e_1_2_7_16_1","first-page":"A537","article-title":"Pathological investigation of essential tremor","volume":"62","author":"Ross GW","year":"2004","journal-title":"Neurology"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00549-0"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.06.009"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(03)00143-7"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.03.007"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2011.01573.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.11.004"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2003.10.007"},{"key":"e_1_2_7_24_1","first-page":"416","article-title":"The NEDICES cohort of the elderly. 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