{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:17:07Z","timestamp":1792016227155,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T00:00:00Z","timestamp":1373500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009810","name":"Johns Hopkins Brain Science Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009810","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"the National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","award":["NS016375"],"award-info":[{"award-number":["NS016375"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","award":["P50AG005146"],"award-info":[{"award-number":["P50AG005146"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","award":["P41 EB015909"],"award-info":[{"award-number":["P41 EB015909"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","award":["NIH-T32MH015330"],"award-info":[{"award-number":["NIH-T32MH015330"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Neurovascular alterations have been implicated in the pathophysiology of Huntington's disease (HD). Because arterioles are most responsive to metabolic alterations, arteriolar cerebral blood volume (CBV\n                      <jats:sub>a<\/jats:sub>\n                      ) is an important indicator of cerebrovascular regulation. The objective of this pilot study was to investigate potential neurovascular (CBV\n                      <jats:sub>a<\/jats:sub>\n                      ) abnormality in prodromal\u2010HD patients and compare it with the widely used imaging marker: brain atrophy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      CBV\n                      <jats:sub>a<\/jats:sub>\n                      and brain volumes were measured with ultra\u2010high\u2010field (7.0\u2010Telsa) magnetic resonance imaging in seven prodromal\u2010HD patients and nine age\u2010matched controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cortical CBV\n                      <jats:sub>a<\/jats:sub>\n                      was elevated significantly in prodromal\u2010HD patients compared with controls (relative difference, 38.5%; effect size, 1.48). Significant correlations were found between CBV\n                      <jats:sub>a<\/jats:sub>\n                      in the frontal cortex and genetic measures. By contrast, no significant brain atrophy was detected in the prodromal\u2010HD patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      CBV\n                      <jats:sub>a<\/jats:sub>\n                      may be abnormal in prodromal\u2010HD, even before substantial brain atrophy occurs. Further investigation with a larger cohort and longitudinal follow\u2010up is merited to determine whether CBV\n                      <jats:sub>a<\/jats:sub>\n                      could be used as a potential biomarker for clinical trials. \u00a9 2013\n                      <jats:italic>Movement<\/jats:italic>\n                      Disorder Society\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.25591","type":"journal-article","created":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T10:48:44Z","timestamp":1373539724000},"page":"396-401","source":"Crossref","is-referenced-by-count":52,"title":["Elevated arteriolar cerebral blood volume in prodromal Huntington's disease"],"prefix":"10.1002","volume":"29","author":[{"given":"Jun","family":"Hua","sequence":"first","affiliation":[{"name":"The Russell H. Morgan Department of Radiology and Radiological Science, Division of Magnetic Resonance Research The Johns Hopkins University School of Medicine Baltimore Maryland USA"},{"name":"F. M. Kirby Research Center for Functional Brain Imaging Kennedy Krieger Institute Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul G.","family":"Unschuld","sequence":"additional","affiliation":[{"name":"Division of Psychiatry Research and Psychogeriatric Medicine University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell L.","family":"Margolis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Johns Hopkins University School of Medicine Baltimore Maryland USA"},{"name":"Department of Neurology and Program in Cellular and Molecular Medicine Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C. M.","family":"van Zijl","sequence":"additional","affiliation":[{"name":"The Russell H. Morgan Department of Radiology and Radiological Science, Division of Magnetic Resonance Research The Johns Hopkins University School of Medicine Baltimore Maryland USA"},{"name":"F. M. Kirby Research Center for Functional Brain Imaging Kennedy Krieger Institute Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Johns Hopkins University School of Medicine Baltimore Maryland USA"},{"name":"Department of Neurology and Program in Cellular and Molecular Medicine Johns Hopkins University School of Medicine Baltimore Maryland USA"},{"name":"Departments of Neuroscience and Pharmacology Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2010.04.003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70276-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70263-0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.208264"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617707071214"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.06.011"},{"key":"e_1_2_9_8_1","first-page":"215","article-title":"Brain white\u2010matter volume loss and glucose hypometabolism precede the clinical symptoms of Huntington's disease","volume":"47","author":"Ciarmiello A","year":"2006","journal-title":"J Nucl Med"},{"key":"e_1_2_9_9_1","first-page":"1591","article-title":"Metabolic network abnormalities in early Huntington's disease: an [(18)F]FDG PET study","volume":"42","author":"Feigin A","year":"2001","journal-title":"J Nucl Med"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870080118"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110612"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.6.2085"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609833104"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0388-12.2012"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2009.06.003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-007-0085-4"},{"key":"e_1_2_9_17_1","first-page":"773","article-title":"Altered patterns of regional cerebral blood flow in patients with Huntington's disease: a SPECT study during rest and cognitive or motor activation","volume":"41","author":"Deckel AW","year":"2000","journal-title":"J Nucl Med"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.9.1667"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2011.60"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.08.112"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.09.003"},{"key":"e_1_2_9_22_1","unstructured":"LinC HuangC LinM et al.Magnetic resonance microscopic angiography visualization of abnormal microvasculature in a transgenic mouse model of Huntington's disease. 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