{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:45:14Z","timestamp":1786632314546,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2013,8,7]],"date-time":"2013-08-07T00:00:00Z","timestamp":1375833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2013,8,7]],"date-time":"2013-08-07T00:00:00Z","timestamp":1375833600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Although essential tremor (ET) is among the most prevalent neurological diseases, its precise pathogenesis is not understood. Purkinje cell loss has been observed in some studies and is the focus of interest and debate. Expressing these data as Purkinje cells\/layer length allows one to adjust for the inherent curved nature of the cerebellar folia. Capitalizing on the Essential Tremor Centralized Brain Repository, we quantified Purkinje cell linear density in cases versus controls. Free\u2010floating 100\u2010\u03bcm parasagittal cerebellar hemispheric sections were subjected to rabbit polyclonal anti\u2010Calbindin D28k antibody, and 10 random fields\/brain were selected for quantification of Purkinje cells\/mm\n                    <jats:sup>\u22121<\/jats:sup>\n                    Purkinje cell layer. Purkinje cell linear density was lower in 32 ET cases than in16 controls (1.14\u2009\u00b1\u20090.32 vs. 1.35\u2009\u00b1\u20090.31\/mm\n                    <jats:sup>\u22121<\/jats:sup>\n                    ,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.03). Purkinje cell linear density was inversely associated with torpedo count (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u22120.38,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.028). The current sample of ET cases demonstrates a reduction in Purkinje cell number relative to that of controls. Greater Purkinje cell axonal remodeling (torpedoes) was found in individuals who had the most Purkinje cell drop out. The role of Purkinje cell loss in the pathogenesis of this disorder merits additional study. \u00a9 2013 International Parkinson and Movement Disorder Society\n                  <\/jats:p>","DOI":"10.1002\/mds.25629","type":"journal-article","created":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T01:06:52Z","timestamp":1375924012000},"page":"1854-1859","source":"Crossref","is-referenced-by-count":66,"title":["Quantification of cerebellar hemispheric purkinje cell linear density: 32 ET cases versus 16 controls"],"prefix":"10.1002","volume":"28","author":[{"given":"Elan D.","family":"Louis","sequence":"first","affiliation":[{"name":"GH Sergievsky Center, College of Physicians and Surgeons Columbia University New York NY USA"},{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain College of Physicians and Surgeons, Columbia University New York New York USA"},{"name":"Department of Neurology College of Physicians and Surgeons, Columbia University New York New York USA"},{"name":"Department of Epidemiology Mailman School of Public Health Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Babij","sequence":"additional","affiliation":[{"name":"GH Sergievsky Center, College of Physicians and Surgeons Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Lee","sequence":"additional","affiliation":[{"name":"GH Sergievsky Center, College of Physicians and Surgeons Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etty","family":"Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Medical Center and the New York Presbyterian Hospital New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Paul G.","family":"Vonsattel","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain College of Physicians and Surgeons, Columbia University New York New York USA"},{"name":"Department of Pathology and Cell Biology Columbia University Medical Center and the New York Presbyterian Hospital New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10376"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22838"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000099075.19951.8C"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000323572"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22370"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)00966-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-009-0111-y"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1544"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.06984.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1190"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70090-9"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm266"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-011-0291-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03598.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.213330"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181d1ad04"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.8.1189"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2007.8"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.01.013"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.06.017"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20583"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02203.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000172352.88359.2d"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(97)00062-6"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-006-0127-z"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00065-9"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(97)00058-4"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000218162.80315.b9"}],"container-title":["Movement 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