{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:05:55Z","timestamp":1792037155809,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T00:00:00Z","timestamp":1381795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T00:00:00Z","timestamp":1381795200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Many people with rapid eye movement (REM) sleep behavior disorder (RBD) have an underlying synucleinopathy, the most common of which is Lewy body disease. Identifying additional abnormal clinical features may help in identifying those at greater risk of evolving to a more severe syndrome. Because gait disorders are common in the synucleinopathies, early abnormalities in gait in those with RBD could help in identifying those at increased risk of developing overt parkinsonism and\/or cognitive impairment. We identified 42 probable RBD subjects and 492 controls using the Mayo Sleep Questionnaire and assessed gait velocity, cadence, and stride dynamics with an automated gait analysis system. Cases and controls were similar in age (79.9\u2009\u00b1\u20094.7 and 80.1\u2009\u00b1\u20094.7,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.74), Unified Parkinson's Disease Rating Scale Part III (UPDRS) score (3.3\u2009\u00b1\u20095.5 and 1.9\u2009\u00b1\u20094.1,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.21) and Mini\u2013Mental State Examination scores (27.2\u2009\u00b1\u20091.9 and 27.7\u2009\u00b1\u20091.6,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.10). A diagnosis of probable RBD was associated with decreased velocity (\u22127.9 cm\/s; 95% confidence interval [CI], \u221213.8 to \u22122.0;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.01), cadence (\u22124.4 steps\/min; 95% CI, \u22127.6 to \u22121.3;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.01), significantly increased double limb support variability (30%; 95% CI, 6\u201360;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.01), and greater stride time variability (29%; 95% CI, 2\u201363;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.03) and swing time variability (46%; 95% CI, 15\u201384;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.01). Probable RBD is associated with subtle gait changes prior to overt clinical parkinsonism. Diagnosis of probable RBD supplemented by gait analysis may help as a screening tool for disorders of \u03b1\u2010synuclein. \u00a9 2013 International Parkinson and Movement Disorder Society\n                  <\/jats:p>","DOI":"10.1002\/mds.25653","type":"journal-article","created":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T12:28:35Z","timestamp":1381840115000},"page":"1847-1853","source":"Crossref","is-referenced-by-count":76,"title":["Subtle gait changes in patients with REM sleep behavior disorder"],"prefix":"10.1002","volume":"28","author":[{"given":"Eric M.","family":"McDade","sequence":"first","affiliation":[{"name":"Department of Neurology Mayo Clinic College of Medicine Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendon P.","family":"Boot","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic College of Medicine Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa J. H.","family":"Christianson","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics Mayo Clinic College of Medicine Rochester Minnesota USA"},{"name":"Department of Health Sciences Research Mayo Clinic College of Medicine Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. Shane","family":"Pankratz","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics Mayo Clinic College of Medicine Rochester Minnesota USA"},{"name":"Department of Health Sciences Research Mayo Clinic College of Medicine Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley F.","family":"Boeve","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic College of Medicine Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanis J.","family":"Ferman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Mayo Clinic College of Medicine Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Bieniek","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic College of Medicine Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Hollman","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Mayo Clinic College of Medicine Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosebud O.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics Mayo Clinic College of Medicine Rochester Minnesota USA"},{"name":"Department of Health Sciences Research Mayo Clinic College of Medicine Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Mielke","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics Mayo Clinic College of Medicine Rochester Minnesota USA"},{"name":"Department of Health Sciences Research Mayo Clinic College of Medicine Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Knopman","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic College of Medicine Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald C.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic College of Medicine Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05115.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70441-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","DOI":"10.1007\/s00415-008-4004-7","volume-title":"Substrates for Normal Gait and Pathophysiology of Gait Disturbances With Respect to the Basal Ganglia 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