{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:55:55Z","timestamp":1791168955039,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T00:00:00Z","timestamp":1382659200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The Unified Huntington's Disease Rating Scale (UHDRS) adequately measures decline in patients at early and moderate stages of Huntington's disease (HD). In advanced patients, floor effects hamper the evaluation, thus calling for an adjusted scale. We designed the UHDRS\u2010For Advanced Patients (UHDRS\u2010FAP), in order to improve longitudinal assessment of patients at advanced disease stage. Sixty\u2010nine patients with a Total Functional Capacity (TFC)\u2009\u2264\u20095 were recruited in France and in the Netherlands. Among them, 45 patients were followed longitudinally (mean 1.6\u2009\u00b1\u20091.2 years) with the UHDRS\u2010FAP; 30 were also assessed with the UHDRS. Cross\u2010sectional analyses evaluated psychometric properties and interrater reliability of the scale. Longitudinal analyses evaluated the sensitivity to decline compared to the UHDRS. Internal consistency was higher for motor and cognitive scores than for somatic and behavioral scores (0.84, 0.91, 0.70, and 0.49, respectively). Interrater reliability was\u2009\u2265\u20090.88 in all scores. The somatic score, specific to the UHDRS\u2010FAP, declined over time, as well as motor and cognitive performance with both scales. Although performance with the 2 scales correlated, the UHDRS\u2010FAP appeared more sensitive to change and was the only scale that detected decline in patients with a TFC\u2009\u2264\u20091. Neither scale detected a significant decline in behavioral scores. The UHDRS\u2010FAP is reliable and more sensitive to change than the original UHDRS for cognitive and motor domains. It offers items relevant for daily care. Behavioral scores tended to decline but this may reflect the decline in the communicative abilities of the patients. \u00a9 2013 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.25654","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T15:27:01Z","timestamp":1382714821000},"page":"1717-1723","source":"Crossref","is-referenced-by-count":26,"title":["Unified Huntington's disease rating scale for advanced patients: Validation and follow\u2010up study"],"prefix":"10.1002","volume":"28","author":[{"given":"Katia","family":"Youssov","sequence":"first","affiliation":[{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2010HP), Centre de r\u00e9f\u00e9rence Maladie de Huntington Groupe Hospitalier Universitaire (GHU) Henri Mondor\u2010Albert Chenevier Cr\u00e9teil France"},{"name":"INSERM U955 Equipe 01 Neuropsychologie interventionnelle Cr\u00e9teil France"},{"name":"Ecole Normale Sup\u00e9rieure Institut d'Etudes Cognitives Paris France"},{"name":"Universit\u00e9 Paris Est Facult\u00e9 de M\u00e9decine Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Dolbeau","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2010HP), Centre de r\u00e9f\u00e9rence Maladie de Huntington Groupe Hospitalier Universitaire (GHU) Henri Mondor\u2010Albert Chenevier Cr\u00e9teil France"},{"name":"INSERM U955 Equipe 01 Neuropsychologie interventionnelle Cr\u00e9teil France"},{"name":"Universit\u00e9 Paris Est Facult\u00e9 de M\u00e9decine Cr\u00e9teil France"},{"name":"Unit\u00e9 de recherche Clinique AP\u2010HP, H\u00f4pital Henri Mondor Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Maison","sequence":"additional","affiliation":[{"name":"INSERM U955 Equipe 01 Neuropsychologie interventionnelle Cr\u00e9teil France"},{"name":"Ecole Normale Sup\u00e9rieure Institut d'Etudes Cognitives Paris France"},{"name":"Universit\u00e9 Paris Est Facult\u00e9 de M\u00e9decine Cr\u00e9teil France"},{"name":"Pharmacologie Clinique AP\u2010HP, H\u00f4pital Henri Mondor Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Fran\u00e7oise","family":"Boiss\u00e9","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2010HP), Centre de r\u00e9f\u00e9rence Maladie de Huntington Groupe Hospitalier Universitaire (GHU) Henri Mondor\u2010Albert Chenevier Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent Cleret","family":"de Langavant","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2010HP), Centre de r\u00e9f\u00e9rence Maladie de Huntington Groupe Hospitalier Universitaire (GHU) Henri Mondor\u2010Albert Chenevier Cr\u00e9teil France"},{"name":"INSERM U955 Equipe 01 Neuropsychologie interventionnelle Cr\u00e9teil France"},{"name":"Ecole Normale Sup\u00e9rieure Institut d'Etudes Cognitives Paris France"},{"name":"Universit\u00e9 Paris Est Facult\u00e9 de M\u00e9decine Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymund A.C.","family":"Roos","sequence":"additional","affiliation":[{"name":"Department of Neurology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Catherine","family":"Bachoud\u2010L\u00e9vi","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2010HP), Centre de r\u00e9f\u00e9rence Maladie de Huntington Groupe Hospitalier Universitaire (GHU) Henri Mondor\u2010Albert Chenevier Cr\u00e9teil France"},{"name":"INSERM U955 Equipe 01 Neuropsychologie interventionnelle Cr\u00e9teil France"},{"name":"Ecole Normale Sup\u00e9rieure Institut d'Etudes Cognitives Paris France"},{"name":"Universit\u00e9 Paris Est Facult\u00e9 de M\u00e9decine Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110204"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870130609"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000198586.85250.13"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20332"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70276-3"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/currents.RRN1206"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/currents.RRN1184"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2006.10.022"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(05)70050-5"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1406"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnn.0000191980.62357.d4"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.31.10.1333"},{"key":"e_1_2_8_15_1","volume-title":"Protocole Toulouse Montr\u00e9al d'Evaluation des Gnosies Visuelles","author":"Agniel A","year":"1992"},{"key":"e_1_2_8_16_1","volume-title":"The Stroop Neurological Screening Test","author":"Trenerry M","year":"1989"},{"key":"e_1_2_8_17_1","first-page":"219","article-title":"Behavioral changes in Huntington's disease","volume":"14","author":"Craufurd D","year":"2001","journal-title":"Neuropsychiatry Neuropsychol Behav Neurol"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2007.11.005"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-011-0215-x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21920"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.2.452"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.25654","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.25654","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.25654","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:18:04Z","timestamp":1760966284000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.25654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1002\/mds.25654"],"URL":"https:\/\/doi.org\/10.1002\/mds.25654","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}