{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:15:36Z","timestamp":1791396936254,"version":"4.3.3"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T00:00:00Z","timestamp":1382313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The pathophysiology underlying freezing of gait (FOG) in Parkinson's disease (PD) is poorly understood. We tested whether gray matter (GM) atrophy contributes to FOG in PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Voxel\u2010based morphometry quantified GM atrophy in 106 patients who were classified as freezers (n\u2009=\u200930) or nonfreezers (n\u2009=\u200976). Well\u2010matched smaller subgroups were also studied. Balance, gait, and cognitive function were assessed, and we evaluated the relationship between GM, FOG severity, and symptoms associated with FOG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>GM was significantly reduced in the inferior parietal lobe and angular gyrus in the matched freezers (n\u2009=\u200922), compared to nonfreezers (n\u2009=\u200922; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.015, cluster\u2010level corrected). In the entire cohort, FOG severity was related to bilateral caudate volumes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>GM atrophy in cortical (i.e., parietal lobe and angular gyrus) and subcortical areas (i.e., caudate) are related to FOG. Disparities among the existing findings suggest that inferences regarding specific brain regions should be made with caution. \u00a9 2013 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.25697","type":"journal-article","created":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T17:14:49Z","timestamp":1382375689000},"page":"134-139","source":"Crossref","is-referenced-by-count":73,"title":["Gray matter atrophy and freezing of gait in Parkinson's disease: Is the evidence black\u2010on\u2010white?"],"prefix":"10.1002","volume":"29","author":[{"given":"Talia","family":"Herman","sequence":"first","affiliation":[{"name":"Movement Disorders Unit Department of Neurology Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"The Dr. Miriam and Sheldon G. Adelson Graduate School of Medicine Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keren","family":"Rosenberg\u2010Katz","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit Department of Neurology Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Functional Brain Center Wohl Institute for Advanced Imaging Tel Aviv Sourasky Medical Center Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Jacob","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit Department of Neurology Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Functional Brain Center Wohl Institute for Advanced Imaging Tel Aviv Sourasky Medical Center Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Giladi","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit Department of Neurology Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Sagol School of Neuroscience Tel Aviv University Tel Aviv Israel"},{"name":"Department of Neurology Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Hausdorff","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit Department of Neurology Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Sagol School of Neuroscience Tel Aviv University Tel Aviv Israel"},{"name":"Harvard Medical School Boston Massachusetts USA"},{"name":"Department of Physical Therapy Sackler Faculty of Medicine Tel Aviv University Tel Aviv 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