{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:52:04Z","timestamp":1791165124567,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,27]],"date-time":"2013-12-27T00:00:00Z","timestamp":1388102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The objective of this study was to evaluate citalopram for executive functioning in Huntington's disease (HD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was randomized, double\u2010blind, and placebo\u2010controlled. Thirty\u2010three adults with HD, cognitive complaints, and no depression (Hamilton Depression [HAM\u2010D] rating scale \u226412) were administered citalopram 20 mg or placebo (7 visits, 20 weeks), with practice and placebo run\u2010ins. The primary outcome was change in executive functioning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The intent to treat analysis was controlled for practice effects, comparing visits 1 and 2 to visits 5 and 6 for citalopram versus placebo. There were no significant benefits on the executive function composite (treatment\u2010placebo mean difference \u22120.167; 95% confidence interval [CI], \u22120.361 to 0.028; <jats:italic>P<\/jats:italic>\u2009=\u2009.092). Citalopram participants showed improved clinician\u2010rated depression symptoms on the HAM\u2010D (<jats:italic>t<\/jats:italic>\u2009=\u2009\u22122.02; <jats:italic>P<\/jats:italic>\u2009=\u20090.05). There were no group differences on motor ratings, self\u2010reported executive functions, psychiatric symptoms, or functional status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was no evidence that short\u2010term treatment with citalopram improved executive functions in HD. Despite excluding patients with active depression, participants on citalopram showed improved mood, raising the possibility of efficacy for subsyndromal depression in HD. \u00a9 2013 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.25750","type":"journal-article","created":{"date-parts":[[2013,12,27]],"date-time":"2013-12-27T09:34:43Z","timestamp":1388136883000},"page":"401-405","source":"Crossref","is-referenced-by-count":61,"title":["Results of the citalopram to enhance cognition in Huntington disease trial"],"prefix":"10.1002","volume":"29","author":[{"given":"Leigh J.","family":"Beglinger","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Iowa Iowa City Iowa USA"},{"name":"Neurological program Elks Rehab Hospital Boise Idaho USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Adams","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Loyola University Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Langbehn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Iowa Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jess G.","family":"Fiedorowicz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Iowa Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Jorge","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Iowa Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Biglan","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Rochester, Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Caviness","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Scottsdale Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blair","family":"Olson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Iowa Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Iowa Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Kieburtz","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Rochester, Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane S.","family":"Paulsen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Iowa Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617798455061"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.7.1329"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.4.658"},{"key":"e_1_2_8_5_1","first-page":"452","article-title":"Rate of functional decline in Huntington's disease","volume":"54","author":"Marder K","year":"2000","journal-title":"Huntington Study Group. Neurology"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.58.5.598"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617701711095"},{"key":"e_1_2_8_8_1","first-page":"15","article-title":"Huntington's disease: cognitive and psychiatric features","volume":"3","author":"Shoulson I","year":"1990","journal-title":"Neuropsychiatry Neuropsychol Behav Neurol"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.9.1179"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(87)90639-2"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410220318"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1980.01780160095011"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03169.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20075"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.01084.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.721773.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04365.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870120319"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.29.1.1"},{"key":"e_1_2_8_20_1","volume-title":"Contributions to Neuropsychological Assessment: A Clinical Manual","author":"Benton AL","year":"1983"},{"key":"e_1_2_8_21_1","author":"Smith A","year":"1982","journal-title":"Symbol Digit Modalities Test (SDMT) Manual (Revised)"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0054651"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.2466\/pms.1958.8.3.271"},{"key":"e_1_2_8_24_1","volume-title":"Wechsler Adult Intelligence Scale","author":"Wechsler D","year":"1997"},{"key":"e_1_2_8_25_1","first-page":"453","volume-title":"A Compendium of Neuropsychological Tests","author":"Tombaugh TN","year":"1996"},{"key":"e_1_2_8_26_1","volume-title":"Wide Range Achievement Test 4 Professional Manual","author":"Wilkinson GS","year":"2006"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/12.8.739"},{"key":"e_1_2_8_28_1","volume-title":"Conners' Adult ADHD Rating Scales (CAARS)","author":"Conners C","year":"1999"},{"key":"e_1_2_8_29_1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1176\/jnp.16.3.315","article-title":"Citalopram treatment of depression in Parkinson's disease: the impact on anxiety, disability, and cognition","volume":"16","author":"Menza M","year":"2004","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.113.494.83"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.5_Suppl_6.10S"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533558"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.8.3.338"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000575"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1943"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.25750","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.25750","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:39:19Z","timestamp":1760953159000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.25750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,27]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1002\/mds.25750"],"URL":"https:\/\/doi.org\/10.1002\/mds.25750","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,27]]}}}