{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:43:24Z","timestamp":1761007404840,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,12,27]],"date-time":"2013-12-27T00:00:00Z","timestamp":1388102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Spinocerebellar ataxia type 2 (SCA2) is an autosomal\u2010dominant degenerative disorder that is neuropathologically characterized primarily by infratentorial damage, although less severe supratentorial involvement may contribute to the clinical manifestation. Diffusion\u2010weighted imaging (DWI)\u2013Magnetic Resonance Imaging (MRI) studies of SCA2 have enabled in vivo quantification of neurodegeneration in infratentorial regions, whereas supratentorial regions have been explored less thoroughly. We measured microstructural changes in both infratentorial and supratentorial regions in 13 SCA2 patients (9 men, 4 women; mean age, 50\u2009\u00b1\u200912 years) and 15 controls (10 men, 5 women; mean age, 49\u2009\u00b1\u200914 years) using DWI\u2010MRI and correlated the DWI changes with disease severity and duration. Disease severity was evaluated using the International Cooperative Ataxia Rating Scale and the Inherited Ataxia Clinical Rating Scale. Cerebral diffusion trace (\n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mds25757-math-0001.gif\" xlink:title=\"urn:x-wiley:08853185:media:mds25757:mds25757-math-0001\"\/>) values were generated, and regions of interest (ROIs) and voxel\u2010based analysis with Statistical Parametric Mapping (SPM) were used for data analysis. In SCA2 patients, ROI analysis and SPM confirmed significant increases in \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mds25757-math-0002.gif\" xlink:title=\"urn:x-wiley:08853185:media:mds25757:mds25757-math-0002\"\/> values in the pons, cerebellar white matter (CWM) and middle cerebellar peduncles. Moreover, SPM analysis revealed increased \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mds25757-math-0003.gif\" xlink:title=\"urn:x-wiley:08853185:media:mds25757:mds25757-math-0003\"\/> values in the right thalamus, bilateral temporal cortex\/white matter, and motor cortex\/pyramidal tract regions. Increased diffusivity in the frontal white matter (FWM) and the CWM was significantly correlated with ataxia severity. DWI\u2010MRI revealed that both infratentorial and supratentorial microstructural changes may characterize SCA2 patients in the course of the disease and might contribute to the severity of the symptoms. \u00a9 2013 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.25757","type":"journal-article","created":{"date-parts":[[2013,12,27]],"date-time":"2013-12-27T09:36:39Z","timestamp":1388136999000},"page":"780-786","source":"Crossref","is-referenced-by-count":18,"title":["Supratentorial and infratentorial damage in spinocerebellar ataxia 2: A diffusion\u2010weighted MRI study"],"prefix":"10.1002","volume":"29","author":[{"given":"Elena","family":"Salvatore","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Reproductive Sciences and Odontostomatology University of Naples Federico II Naples 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