{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:39:31Z","timestamp":1781325571291,"version":"3.54.1"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,12,27]],"date-time":"2013-12-27T00:00:00Z","timestamp":1388102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We explored whether a noninvasive handheld device using Active Cancellation of Tremor (ACT) technology could stabilize tremor\u2010induced motion of a spoon in individuals with essential tremor (ET).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen ET subjects (9 men, 6 women) performed 3 tasks with the ACT device turned on and off. Tremor severity was rated with the Fahn\u2010Tolosa\u2010Marin Tremor Rating Scale (TRS). Subjective improvement was rated by subjects with the Clinical Global Impression Scale (CGI\u2010S). Tremor amplitude was measured using device\u2010embedded accelerometers in 11 subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TRS scores improved with ACT on (versus off) in all 3 tasks: holding (1.00\u2009\u00b1\u20090.76 vs. 0.27\u2009\u00b1\u20090.70; <jats:italic>P<\/jats:italic>\u2009=\u20090.016), eating (1.47\u2009\u00b1\u20091.06 vs. 0.13\u2009\u00b1\u20090.64; <jats:italic>P<\/jats:italic>\u2009=\u20090.001), and transferring (1.33\u2009\u00b1\u20090.82 vs. 0.27\u2009\u00b1\u20090.59; <jats:italic>P<\/jats:italic>\u2009=\u20090.001). CGI\u2010S improved with eating and transferring, but not the holding task. Accelerometer measurements demonstrated 71% to 76% reduction in tremor with the ACT device on.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This noninvasive handheld ACT device can reduce tremor amplitude and severity for eating and transferring tasks in individuals with ET. \u00a9 2013 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.25796","type":"journal-article","created":{"date-parts":[[2013,12,27]],"date-time":"2013-12-27T15:30:05Z","timestamp":1388158205000},"page":"838-842","source":"Crossref","is-referenced-by-count":45,"title":["A noninvasive handheld assistive device to accommodate essential tremor: A pilot study"],"prefix":"10.1002","volume":"29","author":[{"given":"Anupam","family":"Pathak","sequence":"first","affiliation":[{"name":"Lift Labs Design San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Redmond","sequence":"additional","affiliation":[{"name":"Lift Labs Design San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Allen","sequence":"additional","affiliation":[{"name":"Lift Labs Design San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin L.","family":"Chou","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Neurosurgery University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-52014-2.00033-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70322-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2003.98.4.0779"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870131303"},{"key":"e_1_2_9_6_1","first-page":"271","volume-title":"Parkinson's Disease and Movement Disorders","author":"Fahn S","year":"1993"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.50.5.561"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2010.12.016"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/95.3.579"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.38.3.259"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2007.903917"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/14734220601103037"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1109\/ROBOT.2005.1570451"},{"key":"e_1_2_9_14_1","first-page":"827","volume-title":"Assistive Technology\u2014Shaping the Future","author":"Rocon E","year":"2003"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.25796","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.25796","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:06:27Z","timestamp":1760965587000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.25796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,27]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1002\/mds.25796"],"URL":"https:\/\/doi.org\/10.1002\/mds.25796","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,27]]}}}