{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:37:14Z","timestamp":1790087834265,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T00:00:00Z","timestamp":1390262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Essential tremor (ET) is the most common movement disorder among adults. Cerebellar dysfunction is thought to be involved in the pathogenesis of ET; however, imaging, electrophysiological studies, and clinical observations have suggested that the cerebral cortex also may participate. We sought to investigate the possible motor cortical contribution to ET by assessing response to continuous theta\u2010burst stimulation (cTBS), a recognized tool that can produce transient plastic changes, in the primary motor and premotor cortex of patients with ET. We compared parameters, including motor\u2010evoked potential amplitude, cortical silent period, and short\u2010interval intracortical inhibition, before and after applying cTBS in healthy controls and patients with ET. We found that, although cTBS applied to either the motor or premotor cortex was capable of producing a suppressive effect on motor cortical excitability in ET patients, the effects lasted for a significantly shorter time compared with the effect produced in healthy individuals. The change seen in measures of intracortical inhibition after motor cortical or premotor cTBS in healthy controls was reduced or absent in the ET patients. Tremor amplitude was decreased significantly after applying cTBS over either the motor or premotor cortex, but the tremor frequency remained unchanged. These findings suggest that inhibitory circuits within the motor cortex are aberrant and less modifiable in ET patients. The reduced plasticity in response to motor and premotor TBS supports the theory of abnormal gamma\u2010aminobutyric acid (GABA) modulation in ET. \u00a9 2014 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.25809","type":"journal-article","created":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T14:44:16Z","timestamp":1390315456000},"page":"501-507","source":"Crossref","is-referenced-by-count":49,"title":["Reduced cortical plasticity and GABAergic modulation in essential tremor"],"prefix":"10.1002","volume":"29","author":[{"given":"Wen\u2010Li","family":"Chuang","sequence":"first","affiliation":[{"name":"Movement Disorder Section Department of Neurology Chang Gung Memorial Hospital and Chang Gung University College of Medicine Taoyuan Taiwan"},{"name":"Neuroscience Research Center Chang Gung Memorial Hospital Linkou Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Zu","family":"Huang","sequence":"additional","affiliation":[{"name":"Movement Disorder Section Department of Neurology Chang Gung Memorial Hospital and Chang Gung University College of Medicine Taoyuan Taiwan"},{"name":"Neuroscience Research Center Chang Gung Memorial Hospital Linkou Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin\u2010Song","family":"Lu","sequence":"additional","affiliation":[{"name":"Movement Disorder Section Department of Neurology Chang Gung Memorial Hospital and Chang Gung University College of Medicine Taoyuan Taiwan"},{"name":"Neuroscience Research Center Chang Gung Memorial Hospital Linkou Taoyuan Taiwan"},{"name":"Healthy Aging Rearch Center and College of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rou\u2010Shayn","family":"Chen","sequence":"additional","affiliation":[{"name":"Movement Disorder Section Department of Neurology Chang Gung Memorial Hospital and Chang Gung University College of Medicine Taoyuan Taiwan"},{"name":"Neuroscience Research Center Chang Gung Memorial Hospital Linkou Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,21]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1804","volume-title":"Prevalence of essential tremor. 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