{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:08:03Z","timestamp":1789520883087,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T00:00:00Z","timestamp":1391040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Olfactory dysfunction is often associated with Parkinson's disease (PD) and can precede characteristic motor symptoms by several years. Olfactory\u2010related cortical atrophy has been reported in PD, although the extent and association between cortical atrophy and olfactory dysfunction have been controversial. The present study examined whether olfactory dysfunction is associated with gray matter (GM) volume in brain regions subserving primary and secondary olfactory processing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>High\u2010resolution T1\u2010weighted brain MRIs were acquired from 40 PD without dementia and 40 matched controls along with smell identification scores. Brain volumes were compared using voxel\u2010based morphometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to controls, PD patients sustained greater GM loss localized to bilateral piriform cortex (PC) and orbitofrontal cortex (OFC). Reduced olfactory performance in PD was significantly associated with lower GM volumes in PC and OFC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both primary and secondary olfactory cortical atrophy occurred in PD and were associated with olfactory dysfunction. \u00a9 2014 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.25829","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T15:43:31Z","timestamp":1391096611000},"page":"1205-1208","source":"Crossref","is-referenced-by-count":56,"title":["Olfactory\u2010related cortical atrophy is associated with olfactory dysfunction in Parkinson's disease"],"prefix":"10.1002","volume":"29","author":[{"given":"Eun\u2010Young","family":"Lee","sequence":"first","affiliation":[{"name":"Departments of Neurology Pennsylvania State University\u2010Milton S. Hershey Medical Center Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Eslinger","sequence":"additional","affiliation":[{"name":"Departments of Neurology Pennsylvania State University\u2010Milton S. Hershey Medical Center Hershey Pennsylvania USA"},{"name":"Public Health Sciences Pennsylvania State University\u2010Milton S. Hershey Medical Center Hershey Pennsylvania USA"},{"name":"Radiology Pennsylvania State University\u2010Milton S. Hershey Medical Center Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangwei","family":"Du","sequence":"additional","affiliation":[{"name":"Departments of Neurology Pennsylvania State University\u2010Milton S. Hershey Medical Center Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Kong","sequence":"additional","affiliation":[{"name":"Public Health Sciences Pennsylvania State University\u2010Milton S. Hershey Medical Center Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mechelle M.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Departments of Neurology Pennsylvania State University\u2010Milton S. Hershey Medical Center Hershey Pennsylvania USA"},{"name":"Pharmacology Pennsylvania State University\u2010Milton S. Hershey Medical Center Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Huang","sequence":"additional","affiliation":[{"name":"Departments of Neurology Pennsylvania State University\u2010Milton S. Hershey Medical Center Hershey Pennsylvania USA"},{"name":"Pharmacology Pennsylvania State University\u2010Milton S. Hershey Medical Center Hershey Pennsylvania USA"},{"name":"Radiology Pennsylvania State University\u2010Milton S. Hershey Medical Center Hershey Pennsylvania USA"},{"name":"Neurosurgery Pennsylvania State University\u2010Milton S. Hershey Medical Center Hershey Pennsylvania USA"},{"name":"Kinesiology Pennsylvania State University\u2010Milton S. 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