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Fenobam, a negative modulator of metabotropic glutamate receptor subtype 5, has recently been reported to attenuate LID in MPTP\u2010treated macaques. The aim of the current study was to investigate the treatment interactions of fenobam and amantadine on LID in the MPTP\u2010treated macaque model of PD. The antidyskinetic and \u2010parkinsonian effects were measured after administration of fenobam (10\u201030 mg\/kg) and amantadine (10\u201030 mg\/kg) alone and in combination. Fenobam (30 mg\/kg) and amantadine (30 mg\/kg) alone reduced LID, whereas lower doses of either drug did not cause any significant effects. A combined treatment of fenobam and amantadine at subthreshold doses (10 and 20 mg\/kg) significantly reduced LID without worsening PD disability. These data suggest that a low\u2010dose combination of fenobam and amantadine can be used for alleviating dyskinesia without causing adverse motor effects. Such combined therapies may offer a new therapeutic strategy for treatment of LID in PD patients. \u00a9 2014 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.25859","type":"journal-article","created":{"date-parts":[[2014,3,7]],"date-time":"2014-03-07T11:28:37Z","timestamp":1394191717000},"page":"772-779","source":"Crossref","is-referenced-by-count":41,"title":["Combined fenobam and amantadine treatment promotes robust antidyskinetic effects in the 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine (MPTP)\u2010lesioned primate model of Parkinson's disease"],"prefix":"10.1002","volume":"29","author":[{"given":"Wai Kin D.","family":"Ko","sequence":"first","affiliation":[{"name":"Motac Neuroscience Ltd Manchester United Kingdom"},{"name":"Universit\u00e9 de Bordeaux Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives UMR 5293 Bordeaux France"},{"name":"CNRS Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives UMR 5293 Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Pioli","sequence":"additional","affiliation":[{"name":"Motac Neuroscience Ltd Manchester United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Animal Sciences China Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"McGuire","sequence":"additional","affiliation":[{"name":"Motac Neuroscience Ltd Manchester United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Dufour","sequence":"additional","affiliation":[{"name":"The Michael J. 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