{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T10:41:35Z","timestamp":1785580895095,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T00:00:00Z","timestamp":1396828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A subclinical, hepatic involvement in manifest and premanifest Huntington's disease (HD) was recently demonstrated by using the <jats:sup>1<\/jats:sup><jats:sup>3<\/jats:sup>C\u2010methionine breath test (MeBT). In this longitudinal pilot study, we investigated whether there is evidence for progressive hepatic mitochondrial dysfunction in premanifest HD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The MeBT was performed within a group of 25 well\u2010characterized premanifest HD mutation carriers at baseline and in a 14.5\u2010month follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total group of mutation carriers (<jats:italic>P<\/jats:italic>\u2009=\u20090.033; Cohen's d\u2009=\u20090.6) and the subgroup of mutation carriers from our PreHD\u2010B subgroup (nearer to disease onset; <jats:italic>P<\/jats:italic>\u2009=\u20090.030; Cohen's d\u2009=\u20091.12) revealed a lower amount of exhaled <jats:sup>13<\/jats:sup>CO<jats:sub>2<\/jats:sub> in the follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates <jats:italic>in vivo<\/jats:italic> progressive, subclinical, hepatic involvement in premanifest HD. Limitations of the study, such as high variance in breath test results, are discussed. &amp;copy 2014 International Parkinson and Movement Disorder Society \u00a9 2014 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.25862","type":"journal-article","created":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T07:55:16Z","timestamp":1396857316000},"page":"831-834","source":"Crossref","is-referenced-by-count":30,"title":["Progressive hepatic mitochondrial dysfunction in premanifest Huntington's disease"],"prefix":"10.1002","volume":"29","author":[{"given":"Rainer","family":"Hoffmann","sequence":"first","affiliation":[{"name":"Department of Neurology, Huntington Center NRW Ruhr\u2010University Bochum St. Josef\u2010Hospital Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven H.","family":"St\u00fcwe","sequence":"additional","affiliation":[{"name":"Department of Neurology, Huntington Center NRW Ruhr\u2010University Bochum St. Josef\u2010Hospital Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Goetze","sequence":"additional","affiliation":[{"name":"Division of Hepatology, Department of Medicine II University Hospital Wurzburg Wurzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Banasch","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Ruhr\u2010University Bochum St. Josef\u2010Hospital Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Klotz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Huntington Center NRW Ruhr\u2010University Bochum St. Josef\u2010Hospital Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Lukas","sequence":"additional","affiliation":[{"name":"Department of Radiology Ruhr\u2010University Bochum St. 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