{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T12:32:42Z","timestamp":1771763562479,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,4,13]],"date-time":"2014-04-13T00:00:00Z","timestamp":1397347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the current study was to distinguish patients who had tremor\u2010dominant Parkinson's disease (tPD) from those who had essential tremor with rest tremor (rET).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We combined voxel\u2010based morphometry\u2010derived gray matter and white matter volumes and diffusion tensor imaging\u2010derived mean diffusivity and fractional anisotropy in a support vector machine (SVM) to evaluate 15 patients with rET and 15 patients with tPD. Dopamine transporter single\u2010photon emission computed tomography imaging was used as ground truth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SVM classification of individual patients showed that no single predictor was able to fully discriminate patients with tPD from those with rET. By contrast, when all predictors were combined in a multi\u2010modal algorithm, SVM distinguished patients with rET from those with tPD with an accuracy of 100%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SVM is an operator\u2010independent and automatic technique that may help distinguish patients with tPD from those with rET at the individual level. \u00a9 2014 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.25869","type":"journal-article","created":{"date-parts":[[2014,4,13]],"date-time":"2014-04-13T20:20:39Z","timestamp":1397420439000},"page":"1216-1219","source":"Crossref","is-referenced-by-count":41,"title":["Magnetic resonance support vector machine discriminates essential tremor with rest tremor from tremor\u2010dominant Parkinson disease"],"prefix":"10.1002","volume":"29","author":[{"given":"Andrea","family":"Cherubini","sequence":"first","affiliation":[{"name":"Neuroimaging Research Unit Institute of Molecular Bioimaging and Physiology\u2010National Research Council Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Nistic\u00f3","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Unit Institute of Molecular Bioimaging and Physiology\u2010National Research Council Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana","family":"Novellino","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Unit Institute of Molecular Bioimaging and Physiology\u2010National Research Council Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Salsone","sequence":"additional","affiliation":[{"name":"Institute of Neurology Magna Graecia University Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Nigro","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Unit Institute of Molecular Bioimaging and Physiology\u2010National Research Council Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Donzuso","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Unit Institute of Molecular Bioimaging and Physiology\u2010National Research Council Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo","family":"Quattrone","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Unit Institute of Molecular Bioimaging and Physiology\u2010National Research Council Catanzaro Italy"},{"name":"Institute of Neurology Magna Graecia University Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1586\/ern.12.49"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.3.405"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-010-1664-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70214-9"},{"key":"e_1_2_7_6_1","article-title":"Neuroimaging of essential tremor: what is the evidence for cerebellar involvement [serial online]?","volume":"2","author":"Passamonti L","year":"2012","journal-title":"Tremor Other Hyperkinet Mov (NY)"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25491"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)00111-8"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.582"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.11.002"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25737"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032441"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047714"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.01.008"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws084"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3126"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-012-2579-y"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.1.33"},{"issue":"3","key":"e_1_2_7_19_1","first-page":"2","article-title":"Consensus statement of the Movement Disorder Society on tremor","volume":"13","author":"Deuschl G","year":"1998","journal-title":"Mov Disord"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.015"},{"key":"e_1_2_7_21_1","first-page":"3","article-title":"LIBSVM: a library for support vector machines","volume":"2","author":"Chang C\u2010C","year":"2011","journal-title":"ACM T Intel Syst Technol"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1162\/153244303322753616"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.08.037"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1190"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d5a460"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.01.006"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25263"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq212"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03474.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.06.035"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-091186"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.25869","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.25869","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.25869","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:48:02Z","timestamp":1760968082000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.25869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,13]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1002\/mds.25869"],"URL":"https:\/\/doi.org\/10.1002\/mds.25869","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,13]]}}}