{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:05:51Z","timestamp":1791187551225,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T00:00:00Z","timestamp":1400198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Impulse control disorders (ICD) are relatively common in Parkinson's disease (PD) and generally are regarded as adverse effects of dopamine replacement therapy, although certain demographic and clinical risk factors are also involved. Previous single\u2010photon emission computed tomography (SPECT) studies showed reduced ventral striatal dopamine transporter binding in Parkinson patients with ICD compared with patients without. Nevertheless, these studies were performed in patients with preexisting impulse control impairments, which impedes clear\u2010cut interpretation of these findings. We retrospectively procured follow\u2010up data from 31 medication\u2010na\u00efve PD patients who underwent dopamine transporter SPECT imaging at baseline and were subsequently treated with dopamine replacement therapy. We used questionnaires and a telephone interview to assess medication status and ICD symptom development during the follow\u2010up period (31.5\u2009\u00b1\u200912.0 months). Eleven patients developed ICD symptoms during the follow\u2010up period, eight of which were taking dopamine agonists. The PD patients with ICD symptoms at follow\u2010up had higher baseline depressive scores and lower baseline dopamine transporter availability in the right ventral striatum, anterior\u2010dorsal striatum, and posterior putamen compared with PD patients without ICD symptoms. No baseline between\u2010group differences in age and disease stage or duration were found. The ICD symptom severity correlated negatively with baseline dopamine transporter availability in the right ventral and anterior\u2010dorsal striatum. The results of this preliminary study show that reduced striatal dopamine transporter availability predates the development of ICD symptoms after dopamine replacement therapy and may constitute a neurobiological risk factor related to a lower premorbid dopamine transporter availability or a more pronounced dopamine denervation in PD patients susceptible to ICD. \u00a9 2014 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.25886","type":"journal-article","created":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T04:56:17Z","timestamp":1400216177000},"page":"904-911","source":"Crossref","is-referenced-by-count":107,"title":["Reduced dopamine transporter binding predates impulse control disorders in Parkinson's disease"],"prefix":"10.1002","volume":"29","author":[{"given":"Chris","family":"Vriend","sequence":"first","affiliation":[{"name":"Department of Psychiatry VU University Medical Center Amsterdam The Netherlands"},{"name":"Department of Anatomy &amp; Neurosciences VU University Medical Center Amsterdam The Netherlands"},{"name":"Neuroscience Campus Amsterdam VU\/VUmc Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna H.","family":"Nordbeck","sequence":"additional","affiliation":[{"name":"Department of Anatomy &amp; Neurosciences VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Booij","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ysbrand D.","family":"van der Werf","sequence":"additional","affiliation":[{"name":"Department of Anatomy &amp; Neurosciences VU University Medical Center Amsterdam The Netherlands"},{"name":"Neuroscience Campus Amsterdam VU\/VUmc Amsterdam The Netherlands"},{"name":"Netherlands Institute for Neuroscience Royal Netherlands Academy of Arts and Sciences Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommy","family":"Pattij","sequence":"additional","affiliation":[{"name":"Department of Anatomy &amp; Neurosciences VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Voorn","sequence":"additional","affiliation":[{"name":"Department of Anatomy &amp; Neurosciences VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Raijmakers","sequence":"additional","affiliation":[{"name":"Department of Radiology &amp; Nuclear Medicine VU University Medical Center (VUmc) Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth M.J.","family":"Foncke","sequence":"additional","affiliation":[{"name":"Department of Neurology VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsmarieke","family":"van de Giessen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk W.","family":"Berendse","sequence":"additional","affiliation":[{"name":"Department of Neurology VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile A.","family":"van den Heuvel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry VU University Medical Center Amsterdam The Netherlands"},{"name":"Department of Anatomy &amp; Neurosciences VU University Medical Center Amsterdam The Netherlands"},{"name":"Neuroscience Campus Amsterdam VU\/VUmc Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.65"},{"key":"e_1_2_8_3_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70287-X"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.09.007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp054"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr003"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-305395"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.03.013"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23480"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181fc27fa"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/854524"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.11.073"},{"key":"e_1_2_8_14_1","first-page":"165","article-title":"Parkinson's Disease Society Brain Bank, London: overview and research","volume":"39","author":"Daniel SE","year":"1993","journal-title":"J Neural Transm Suppl"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-007-0621-0"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24023"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200932060-00004"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22505"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.02.029"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22571"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-012-2276-8"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10579"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.84"},{"key":"e_1_2_8_24_1","doi-asserted-by":"crossref","unstructured":"DreherJC KohnP KolachanaB WeinbergerDR BermanKF.Variation in dopamine genes influences responsivity of the human reward system.Proc Natl Acad Sci U S A2009;106:617\u2010622.","DOI":"10.1073\/pnas.0805517106"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21505"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1102941"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2576-x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0533-x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.06.021"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1185778"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-12-05042.2002"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.08.030"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00516.2010"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-304811"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2396(200102)39:2<101::AID-SYN1>3.0.CO;2-1"},{"key":"e_1_2_8_36_1","first-page":"1143","article-title":"Iodine\u2010123\u2010N\u2010omega\u2010fluoropropyl\u20102beta\u2010carbomethoxy\u20103beta\u2010(4\u2010iod ophenyl)tropane SPECT in healthy controls and early\u2010stage, drug\u2010naive Parkinson's disease","volume":"39","author":"Tissingh G","year":"1998","journal-title":"J Nucl Med"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22356"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6645-9"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25291"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.25886","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.25886","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:39:23Z","timestamp":1760956763000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.25886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,16]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1002\/mds.25886"],"URL":"https:\/\/doi.org\/10.1002\/mds.25886","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,16]]}}}