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We examined 97 PD patients and 32 healthy controls (HC) with spectral\u2010domain optical coherence tomography (OCT), including intra\u2010retinal layer segmentation. In total, we compared 111 retinal nerve fiber layer (RNFL)\u2010scans and 114 macula scans from 68 PD patients with 62 RNFL and 63 macula scans from 32 HC. For clinical evaluation of disease severity, we used the Unified Parkinson's Disease Rating Scale (UPDRS) motor examination. To determine color discrimination, we performed the Farnsworth Munsell 100 Hue Test (FMT) in a subgroup of PD patients. We found significant combined outer nuclear and photoreceptor layer thinning in PD versus HC (118.6 vs. 123.5 \u00b5m, <jats:italic>P<\/jats:italic>\u2009=\u20090.001). Differences in RNFL, total macular volume, or the other retinal layer thicknesses were not detected. The OCT measures were not associated with disease severity, duration, or color vision. By showing photoreceptor cell layer thinning, our findings support previous in vivo and autopsy studies demonstrating retinal alterations in PD. Optical coherence tomography may help to assess morphological retinal changes in PD patients; however, the utility of OCT in routine clinical practice may be limited because many PD patients have difficulties complying with OCT investigation because of disease\u2010related symptoms such as tremor, axial rigidity, or cognitive impairment. \u00a9 2014 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.25896","type":"journal-article","created":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T19:10:53Z","timestamp":1398885053000},"page":"1163-1170","source":"Crossref","is-referenced-by-count":86,"title":["Photoreceptor layer thinning in idiopathic Parkinson's disease"],"prefix":"10.1002","volume":"29","author":[{"given":"Nicolas M.","family":"Roth","sequence":"first","affiliation":[{"name":"NeuroCure Clinical Research Center Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin  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