{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T08:37:24Z","timestamp":1769157444971,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,6,7]],"date-time":"2014-06-07T00:00:00Z","timestamp":1402099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>The neurophysiological characteristics of motor cortex have been well characterized in patients with Huntington's disease. We present the first data on cortical excitability in patients with Sydenham's chorea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Motor cortex excitability was examined using transcranial magnetic stimulation in 16 patients in the early clinical stages of Sydenham's chorea and in 17 age\u2010 and sex\u2010matched control subjects. Investigations included resting and active motor threshold, motor evoked potential, input\u2013output curves, contralateral silent period, and transcallosal inhibition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Resting and active motor threshold were significantly higher and motor evoked potentials were significantly smaller in patients in comparison with controls. The input\u2013output curves were shallower in both hemispheres of patients with chorea compared with controls. No significant differences were seen in silent period or transcallosal inhibition duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sydenham's chorea is characterized by reduced excitability of corticospinal output similar to that observed in Huntington's disease. \u00a9 2014 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.25928","type":"journal-article","created":{"date-parts":[[2014,6,7]],"date-time":"2014-06-07T07:05:33Z","timestamp":1402124733000},"page":"259-262","source":"Crossref","is-referenced-by-count":17,"title":["Changes in motor cortical excitability in patients with Sydenham's chorea"],"prefix":"10.1002","volume":"30","author":[{"given":"Eman M.","family":"Khedr","sequence":"first","affiliation":[{"name":"Departments of Neuropsychiatry, Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Departments of Neuropsychiatry, Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anwar M.","family":"Ali","sequence":"additional","affiliation":[{"name":"Departments of Neuropsychiatry, Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reda","family":"Badry","sequence":"additional","affiliation":[{"name":"Departments of Neuropsychiatry, Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Rothwell","sequence":"additional","affiliation":[{"name":"Sobell Department of Motor Neuroscience and movement Disorders National Hospital for Neurology and Neurosurgery Queen Square London 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