{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:39:17Z","timestamp":1778618357992,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,6,12]],"date-time":"2014-06-12T00:00:00Z","timestamp":1402531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A polymorphism in brain\u2010derived neurotrophic factor (BDNF) (Val66Met) has been reported as a risk factor in primary dystonia. However, overall the results have been inconclusive. Our aim was to clarify the association of Val66Met with primary dystonia, and with the most prevalent clinical subtypes, cervical dystonia and blepharospasm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a Spanish multicenter case\u2010control study (including 680 primary dystonia patients and 788 healthy controls) and performed a meta\u2010analysis integrating our study and six previously published studies (including a total of 1,936 primary dystonia patients and 2,519 healthy controls).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found no allelic or genotypic association with primary dystonia, cervical dystonia, or blepharospasm risks, for the allele A (Met) from a BDNF Val66Met polymorphism in our case\u2010control study. This was confirmed by results from our meta\u2010analysis in white and mixed ethnic populations in any genetic model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We did not find any evidence supporting the association of the BDNF Val66Met polymorphism with primary dystonia. \u00a9 2014 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.25938","type":"journal-article","created":{"date-parts":[[2014,6,12]],"date-time":"2014-06-12T12:02:29Z","timestamp":1402574549000},"page":"1083-1086","source":"Crossref","is-referenced-by-count":9,"title":["BDNF Val66Met polymorphism in primary adult\u2010onset dystonia: A case\u2010control study and meta\u2010analysis"],"prefix":"10.1002","volume":"29","author":[{"given":"Pilar","family":"G\u00f3mez\u2010Garre","sequence":"first","affiliation":[{"name":"Unidad de Trastornos del Movimiento, Servicio de Neurolog\u00eda y Neurofisiolog\u00eda Cl\u00ednica Instituto de Biomedicina 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