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Furthermore, neural correlates of action inhibition in these patients are poorly understood. We performed event\u2010related functional magnetic resonance imaging during a stop\u2010signal reaction\u2010time task in 14 uncomplicated adult Tourette patients and 15 healthy controls. In patients, we correlated activations in stop\u2010signal reaction\u2010time task with their individual motor tic frequency. Task performance was similar in both groups. Activation of dorsal premotor cortex was stronger in the StopSuccess than in the Go condition in healthy controls. This pattern was reversed in Tourette patients. A significant positive correlation was present between motor tic frequency and activations in the supplementary motor area during StopSuccess versus Go in patients. Inhibitory brain networks differ between healthy controls and Tourette patients. In the latter the supplementary motor area is probably a key relay of inhibitory processes mediating both suppression of tics and inhibition of voluntary action. \u00a9 2014 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.25944","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T06:02:21Z","timestamp":1404367341000},"page":"1532-1538","source":"Crossref","is-referenced-by-count":83,"title":["Action inhibition in Tourette syndrome"],"prefix":"10.1002","volume":"29","author":[{"given":"Christos","family":"Ganos","sequence":"first","affiliation":[{"name":"Department of Neurology University Medical Center Hamburg\u2010Eppendorf (UKE) Hamburg Germany"},{"name":"Sobell Department of Motor Neuroscience and Movement Disorders University College London Institute of Neurology London United Kingdom"},{"name":"Department of Paediatric and Adult Movement Disorders and Neuropsychiatry Institute of Neurogenetics, University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"K\u00fchn","sequence":"additional","affiliation":[{"name":"Center for Lifespan Psychology, Max Planck Institute for Human Development Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Kahl","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Hamburg\u2010Eppendorf (UKE) Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odette","family":"Schunke","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Hamburg\u2010Eppendorf (UKE) Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Feldheim","sequence":"additional","affiliation":[{"name":"Brain Imaging and Neurostimulation Laboratory Department of Neurology University Medical Center Hamburg\u2010Eppendorf (UKE) Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gerloff","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Hamburg\u2010Eppendorf (UKE) Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veit","family":"Roessner","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry University of Dresden Medical School Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"B\u00e4umer","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Adult Movement Disorders and Neuropsychiatry Institute of Neurogenetics, University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6tz","family":"Thomalla","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Hamburg\u2010Eppendorf 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