{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:02:27Z","timestamp":1791302547027,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,7,7]],"date-time":"2014-07-07T00:00:00Z","timestamp":1404691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cognitive dysfunction is central to Huntington's disease (HD) and undermines quality of life. Clinical trials are now targeting cognitive outcomes in HD; however, no cognitive battery has been optimized for HD clinical trials. We evaluated 16 cognitive tests in a 20\u2010site, five\u2010country, observational study designed to mimic aspects of a clinical trial (e.g., data collection managed by a contract research organization, repeated testing, prespecified statistical analyses). Fifty\u2010five early HD, 103 premanifest HD (pre\u2010HD), and 105 controls were tested at visit 1, visit 2 (1\u20103 days later), and visit 3 (5\u20107 weeks after visit 1). For inclusion in a recommended battery, tests were evaluated for sensitivity, practice effects, reliability, domain coverage, feasibility, and tolerability. Most tests differentiated controls from pre\u2010HD and early HD and showed excellent psychometric properties. We selected six tests to constitute the Huntington's Disease Cognitive Assessment Battery (HD\u2010CAB): Symbol Digit Modalities Test, Paced Tapping, One Touch Stockings of Cambridge (abbreviated), Emotion Recognition, Trail Making B, and the Hopkins Verbal Learning Test. These tests demonstrated sensitivity to disease status (Cohen's d effect sizes: early HD= \u22121.38 to \u22121.90 and pre\u2010HD= \u22120.41 to \u22120.78), and acceptable reliability (<jats:italic>r<\/jats:italic>'s 0.73\u20100.93). A composite score yielded large effect sizes (early HD\u2009=\u2009\u22122.44 and pre\u2010HD\u2009=\u2009\u22120.87) and high reliability (<jats:italic>r<\/jats:italic>\u2009=\u20090.95). HD\u2010CAB is the first cognitive battery designed specifically for use in late premanifest and early HD clinical trials. Adoption of the HD\u2010CAB will facilitate evaluation of treatments to improve cognition in HD. \u00a9 2014 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.25964","type":"journal-article","created":{"date-parts":[[2014,7,7]],"date-time":"2014-07-07T05:54:15Z","timestamp":1404712455000},"page":"1281-1288","source":"Crossref","is-referenced-by-count":94,"title":["HD\u2010CAB: A cognitive assessment battery for clinical trials in Huntington's disease<sup>1,2,3<\/sup>"],"prefix":"10.1002","volume":"29","author":[{"given":"Julie C.","family":"Stout","sequence":"first","affiliation":[{"name":"School of Psychological Sciences Monash University Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Queller","sequence":"additional","affiliation":[{"name":"Queller Consulting Dunedin Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalyca N.","family":"Baker","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences Monash University Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Cowlishaw","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences Monash University Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Sampaio","sequence":"additional","affiliation":[{"name":"CHDI Management\/CHDI Foundation Princeton New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Fitzer\u2010Attas","sequence":"additional","affiliation":[{"name":"CHDI Management\/CHDI Foundation Princeton New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Borowsky","sequence":"additional","affiliation":[{"name":"CHDI Management\/CHDI Foundation Princeton New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the HD\u2010CAB Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.2.452"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-381328-2.00013-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-40"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-301940"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70276-3"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70088-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000198586.85250.13"},{"key":"e_1_2_8_9_1","first-page":"462","volume-title":"Huntington's Disease","author":"Borowsky B","year":"2014"},{"key":"e_1_2_8_10_1","first-page":"CD006455","article-title":"Therapeutic interventions for disease progression in Huntington's disease","author":"Mestre T","year":"2009","journal-title":"The Cochrane Database of Systematic Reviews"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0020937"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2007.10.030"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-011-0215-x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2741\/S355"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110204"},{"key":"e_1_2_8_16_1","unstructured":"Huntington's Disease Study Group.Huntington's Disease Study Group Unified Huntington's Disease Rating Scale\u201099.Rochester NY 1999."},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410521"},{"key":"e_1_2_8_18_1","unstructured":"UNESCO. 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