{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T21:32:13Z","timestamp":1782509533172,"version":"3.54.5"},"reference-count":61,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T00:00:00Z","timestamp":1405555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Magnetic resonance imaging (MRI) research in identifying altered brain structure and function in ataxia\u2010telangiectasia, an autosomal recessive neurodegenerative disorder, is limited. Diffusion\u2010weighted MRI were obtained from 11 ataxia telangiectasia patients (age range, 7\u201022 years; mean, 12 years) and 11 typically developing age\u2010matched participants (age range, 8\u201023 years; mean, 13 years). Gray matter volume alterations in patients were compared with those of healthy controls using voxel\u2010based morphometry, whereas tract\u2010based spatial statistics was employed to elucidate white matter microstructure differences between groups. White matter microstructure was probed using quantitative fractional anisotropy and mean diffusivity measures. Reduced gray matter volume in both cerebellar hemispheres and in the precentral\u2010postcentral gyrus in the left cerebral hemisphere was observed in ataxia telangiectasia patients compared with controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, corrected for multiple comparisons). A significant reduction in fractional anisotropy in the cerebellar hemispheres, anterior\/posterior horns of the medulla, cerebral peduncles, and internal capsule white matter, particularly in the left posterior limb of the internal capsule and corona radiata in the left cerebral hemisphere, was observed in patients compared with controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Mean diffusivity differences were observed within the left cerebellar hemisphere and the white matter of the superior lobule of the right cerebellar hemisphere (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Cerebellum\u2010localized gray matter changes are seen in young ataxia telangiectasia patients along with white matter tract degeneration projecting from the cerebellum into corticomotor regions. The lack of cortical involvement may reflect early\u2010stage white matter motor pathway degeneration within young patients. \u00a9 2014 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.25970","type":"journal-article","created":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T06:33:32Z","timestamp":1405578812000},"page":"1289-1298","source":"Crossref","is-referenced-by-count":15,"title":["Altered corticomotor\u2010cerebellar integrity in young ataxia telangiectasia patients"],"prefix":"10.1002","volume":"29","author":[{"given":"Ishani","family":"Sahama","sequence":"first","affiliation":[{"name":"The University of Queensland, School of Medicine Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Sinclair","sequence":"additional","affiliation":[{"name":"Neurology The Royal Children's Hospital Brisbane 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