{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:01:39Z","timestamp":1791396099496,"version":"4.3.3"},"reference-count":24,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T00:00:00Z","timestamp":1405987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dopamine transporter imaging is widely used for the differential diagnosis of parkinsonism. Only limited data are available on the relationship between striatal dopamine transporter binding and dopaminergic cell loss in the substantia nigra (SN). We analyzed postmortem SN cell counts in patients who had previously undergone dopamine transporter single\u2010photon emission computed tomography (SPECT). Pathological diagnoses included Parkinson's disease (n\u2009=\u20091), dementia with Lewy bodies (n\u2009=\u20092), multiple system atrophy (n\u2009=\u20091), corticobasal degeneration (n\u2009=\u20092), atypical parkinsonism with multiple pathological conditions (n\u2009=\u20091), Alzheimer's disease (n\u2009=\u20091), and Creutzfeldt\u2010Jakob disease (n\u2009=\u20091). [<jats:sup>12<\/jats:sup><jats:sup>3<\/jats:sup>I]\u03b2\u2010CIT SPECT had been performed in all subjects using a standardized protocol on the same triple\u2010head gamma camera. The density of neuromelanin\u2010containing and tyrosine hydroxylase\u2013positive substantia nigra neurons\/mm<jats:sup>2<\/jats:sup> was evaluated in paraffin\u2010embedded tissue sections by morphometric methods. Mean disease duration at the time of dopamine transporter imaging was 2.3 years, and the mean interval from imaging to death was 29.3 months (range, 4\u201068 months). Visual analysis of dopamine transporter images showed reduced striatal uptake in all seven patients with neurodegenerative parkinsonism, but not in Alzheimer's and Creutzfeldt\u2010Jakob disease cases. Averaged [(right+left)\/2] striatal uptake was highly correlated with averaged SN cell counts (r<jats:sub>s<\/jats:sub>\u2009=\u20090.98, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0005 for neuromelanin\u2010 and r<jats:sub>s<\/jats:sub>\u2009=\u20090.96, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0005 for tyrosine hydroxylase\u2013positive cells). Similar strong correlations were found in separate analyses for the right and left sides. Striatal dopamine transporter binding highly correlated with postmortem SN cell counts, confirming the validity of dopamine transporter imaging as an excellent in vivo marker of nigrostriatal dopaminergic degeneration. \u00a9 2014 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.25975","type":"journal-article","created":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T07:54:17Z","timestamp":1406015657000},"page":"1767-1773","source":"Crossref","is-referenced-by-count":132,"title":["Correlation of striatal dopamine transporter imaging with post mortem substantia nigra cell counts"],"prefix":"10.1002","volume":"29","author":[{"given":"Julia","family":"Kraemmer","sequence":"first","affiliation":[{"name":"Department of Neurology Medical University of Vienna  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor G.","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Institute of Neurology, Medical University of Vienna  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Perju\u2010Dumbrava","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Vienna  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Pirker","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Vienna  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Traub\u2010Weidinger","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine Department of Biomedical Imaging and Image\u2010guided Therapy Medical University of Vienna  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Pirker","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Vienna  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