{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:22:16Z","timestamp":1791861736769,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T00:00:00Z","timestamp":1409097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was undertaken to determine whether the production of melatonin, a hormone regulating sleep in relation to the light\/dark cycle, is altered in Huntington's disease. We analyzed the circadian rhythm of melatonin in a 24\u2010hour study of cohorts of control, premanifest, and stage II\/III Huntington's disease subjects. The mean and acrophase melatonin concentrations were significantly reduced in stage II\/III Huntington's disease subjects compared with controls. We also observed a nonsignificant trend toward reduced mean and acrophase melatonin in premanifest Huntington's disease subjects. Onset of melatonin rise was significantly more temporally spread in both premanifest and stage II\/III Huntington's disease subjects compared with controls. A nonsignificant trend also was seen for reduced pulsatile secretion of melatonin. Melatonin concentrations are reduced in Huntington's disease. Altered melatonin patterns may provide an explanation for disrupted sleep and circadian behavior in Huntington's disease, and represent a biomarker for disease state. Melatonin therapy may help the sleep disorders seen in Huntington's disease. \u00a9 2014 The Authors. <jats:italic>Movement<\/jats:italic> Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.<\/jats:p>","DOI":"10.1002\/mds.26003","type":"journal-article","created":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T09:19:10Z","timestamp":1409131150000},"page":"1511-1515","source":"Crossref","is-referenced-by-count":113,"title":["Plasma melatonin is reduced in Huntington's disease"],"prefix":"10.1002","volume":"29","author":[{"given":"Eirini","family":"Kalliolia","sequence":"first","affiliation":[{"name":"Reta Lila Weston Institute of Neurological Studies Department of Molecular Neurosciences UCL Institute of Neurology London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edina","family":"Silajd\u017ei\u0107","sequence":"additional","affiliation":[{"name":"Brain Disease Biomarker Unit Department of Experimental Medical Science Wallenberg Neuroscience Centre Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajasree","family":"Nambron","sequence":"additional","affiliation":[{"name":"Reta Lila Weston Institute of Neurological Studies Department of Molecular Neurosciences UCL Institute of Neurology London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan R.","family":"Hill","sequence":"additional","affiliation":[{"name":"Nuffield Department of Primary Care Health Sciences University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anisha","family":"Doshi","sequence":"additional","affiliation":[{"name":"Reta Lila Weston Institute of Neurological Studies Department of Molecular Neurosciences UCL Institute of Neurology London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Frost","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics London School of Hygiene and Tropical Medicine London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary","family":"Watt","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care Imperial College London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hindmarsh","sequence":"additional","affiliation":[{"name":"Developmental Endocrinology Research Group UCL Institute of Child Health London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bj\u00f6rkqvist","sequence":"additional","affiliation":[{"name":"Brain Disease Biomarker Unit Department of Experimental Medical Science Wallenberg Neuroscience Centre Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas T.","family":"Warner","sequence":"additional","affiliation":[{"name":"Reta Lila Weston Institute of Neurological Studies Department of Molecular Neurosciences UCL Institute of Neurology London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70178-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/currents.RRN1189"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2008.10.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.4.482"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00314781"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3842-04.2005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.12.011"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2006.05322.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5196-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870130609"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02341.x"},{"key":"e_1_2_8_14_1","first-page":"55","article-title":"Time series analysis in endocrinology","volume":"347","author":"Matthews DR","year":"1988","journal-title":"Acta Paediatr Scand Suppl"},{"key":"e_1_2_8_15_1","unstructured":"HillNR.Analysis of non\u2010steady state physiological and pathological processes Thesis University of Oxford 2008; 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