{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:21:32Z","timestamp":1792009292150,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T00:00:00Z","timestamp":1408665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Levodopa (<jats:sc>l<\/jats:sc>\u2010dopa) therapy in Parkinson's disease (PD) increases serum homocysteine levels because of its metabolism via catechol O\u2010methyltransferase, which may lead to endothelial dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We enrolled 40 PD patients treated with <jats:sc>l<\/jats:sc>\u2010dopa, 33 PD patients treated with <jats:sc>l<\/jats:sc>\u2010dopa\/entacapone, 22 untreated PD and 30 controls, and compared the flow\u2010mediated dilation in these subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The flow\u2010mediated dilation was significantly lower in PD patients with <jats:sc>l<\/jats:sc>\u2010dopa (6.0\u2009\u00b1\u20091.8%) than in those with <jats:sc>l<\/jats:sc>\u2010dopa\/entacapone (7.2\u2009\u00b1\u20091.1%, <jats:italic>P<\/jats:italic>\u2009=\u20090.03), untreated PD patients (7.8\u2009\u00b1\u20091.2%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and controls (8.5\u2009\u00b1\u20092.9%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The homocysteine level was significantly higher in PD patients with <jats:sc>l<\/jats:sc>\u2010dopa than in other groups. In a multivariate logistic regression model, the uppermost homocysteine quartile was an independent predictor of the lowest tertile of flow\u2010mediated dilation (odds ratio, 6.33; 95% confidence interval, 1.61\u201026.65; <jats:italic>P<\/jats:italic>\u2009=\u20090.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings indicate that endothelial dysfunction may be associated with chronic <jats:sc>l<\/jats:sc>\u2010dopa treatment in patients with PD. \u00a9 2014 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26005","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T23:18:58Z","timestamp":1408749538000},"page":"1551-1555","source":"Crossref","is-referenced-by-count":24,"title":["Endothelial dysfunction and hyperhomocysteinemia in Parkinson's disease: Flow\u2010mediated dilation study"],"prefix":"10.1002","volume":"29","author":[{"given":"Jung Han","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Neurology Ajou University School of Medicine Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Soo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Ajou University School of Medicine Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok Woo","family":"Yong","sequence":"additional","affiliation":[{"name":"Department of Neurology Ajou University School of Medicine Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Man","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurology Ajou University School of Medicine Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil Hyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Yonsei University College of Medicine Seoul South 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