{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:51:25Z","timestamp":1791165085709,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T00:00:00Z","timestamp":1408665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2014,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Unraveling the pathophysiology and testing candidate therapeutics in neurodegenerative disorders is, necessarily, highly dependent on model systems. Because Huntington's disease (HD) is caused by a single (expanded CAG tract) mutation in the huntingtin (<jats:italic>HTT)<\/jats:italic> gene, a richness of model systems, particularly mice, have been engineered to both dissect disease mechanisms and test potential therapeutics. Even so, as with other neurodegenerative diseases, very little success has been achieved in translating HD mouse model drug testing results to the clinic. Because of the considerable costs\u2014human, opportunity, and financial\u2014there is a pressing need to improve the use of existing HD models and also to develop models in higher species beyond rodent, such as sheep, minipig, and nonhuman primate, to bridge the translational gap from preclinical to clinical testing of candidate therapeutics. \u00a9 2014 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.26008","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T23:17:06Z","timestamp":1408749426000},"page":"1397-1403","source":"Crossref","is-referenced-by-count":29,"title":["Mind the gap: Models in multiple species needed for therapeutic development in Huntington's disease"],"prefix":"10.1002","volume":"29","author":[{"given":"David S.","family":"Howland","sequence":"first","affiliation":[{"name":"CHDI Management\/CHDI Foundation Princeton New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Munoz\u2010Sanjuan","sequence":"additional","affiliation":[{"name":"CHDI Management\/CHDI Foundation Princeton New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.12.015"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/507423a"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11556"},{"key":"e_1_2_9_5_1","unstructured":"MenalledLM LutzC RambozS BrunnerD LagerB NobleS HowlandD.A Field Guide to Working With Mouse Models of Huntington's Disease. 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