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Additional research indicates that these volumetric measures meet important criteria for a biomarker that can be used in clinical trials: They are 1) objectively measureable; 2) able to predict known endpoints; and 3) associated with known mechanisms of pathology of the disease. Researchers should consider formal application to regulatory agencies for biomarker status of volumetric MRI striatal measures, because these measures are anticipated to contribute significantly in the assessment of treatment effectiveness in HD. \u00a9 2014 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.26013","type":"journal-article","created":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T10:25:55Z","timestamp":1409135155000},"page":"1429-1433","source":"Crossref","is-referenced-by-count":28,"title":["Magnetic resonance imaging striatal volumes: A biomarker for clinical trials in Huntington's disease"],"prefix":"10.1002","volume":"29","author":[{"given":"Elizabeth H.","family":"Aylward","sequence":"first","affiliation":[{"name":"Seattle Children's Research Institute Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2001.113989"},{"key":"e_1_2_7_3_1","first-page":"13","volume-title":"Biomarkers as surrogate endpoints in clinical trials for HIV\/AIDS: a model for other diseases? 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