{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:13:54Z","timestamp":1790561634711,"version":"4.1.0"},"reference-count":90,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T00:00:00Z","timestamp":1417737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Patients with Parkinson's disease (PD) may experience impulse control disorders (ICDs) when on dopamine agonist therapy for their motor symptoms. In the last few years, a rapid growth of interest for the recognition of these aberrant behaviors and their neurobiological correlates has occurred. Recent advances in neuroimaging are helping to identify the neuroanatomical networks responsible for these ICDs, and together with psychopharmacological assessments are providing new insights into the brain status of impulsive behavior. The genetic associations that may be unique to ICDs in PD are also being identified. Complementing human studies, electrophysiological and biochemical studies in animal models are providing insights into neuropathological mechanisms associated with these disorders. New animal models of ICDs in PD patients are being implemented that should provide critical means to identify efficacious therapies for PD\u2010related motor deficits while avoiding ICD side effects. Here, we provide an overview of these recent advances, with a particular emphasis on the neurobiological correlates reported in animal models and patients along with their genetic underpinnings. \u00a9 2014 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.26068","type":"journal-article","created":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T18:12:20Z","timestamp":1418062340000},"page":"141-149","source":"Crossref","is-referenced-by-count":94,"title":["Linking neuroscience with modern concepts of impulse control disorders in Parkinson's disease"],"prefix":"10.1002","volume":"30","author":[{"given":"T. Celeste","family":"Napier","sequence":"first","affiliation":[{"name":"Departments of Pharmacology and Psychiatry Center for Compulsive Behavior and Addiction, Rush University Medical Center Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Christophe","family":"Corvol","sequence":"additional","affiliation":[{"name":"UPMC, APHP, ICM, INSERM CIC\u20101422 and UMRS 1127 Department of Neurology Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony A.","family":"Grace","sequence":"additional","affiliation":[{"name":"Departments of Neuroscience Psychiatry and Psychology Center for Neuroscience, University of Pittsburgh Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie D.","family":"Roitman","sequence":"additional","affiliation":[{"name":"Department of Psychology and Laboratory of Integrative Neuroscience University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences Behavioural and Clinical Neuroscience Institute; and Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Voon","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio P.","family":"Strafella","sequence":"additional","affiliation":[{"name":"Morton and Gloria Shulman Movement Disorder Unit \u2010 E.J. 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