{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:35:04Z","timestamp":1793414104751,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T00:00:00Z","timestamp":1425427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the integrity of the data and the accuracy of the data analysis"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>This study was undertaken to determine the prevalence and correlates of cognitive impairment (CI) and neuropsychiatric symptoms (NPS) in early, untreated patients with Parkinson's disease (PD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Both CI and NPS are common in PD and impact disease course and quality of life. However, limited knowledge is available about cognitive abilities and NPS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Parkinson's Progression Markers Initiative (PPMI) is a multi\u2010site study of early, untreated PD patients and healthy controls (HCs), the latter with normal cognition. At baseline, participants were assessed with a neuropsychological battery and for symptoms of depression, anxiety, impulse control disorders (ICDs), psychosis, and apathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline data of 423 PD patients and 196 HCs yielded no between\u2010group differences in demographic characteristics. Twenty\u2010two percent of PD patients met the PD\u2010recommended screening cutoff for CI on the Montral Cognitive Assessment (MoCA), but only 9% met detailed neuropsychological testing criteria for mild cognitive impairment (MCI)\u2010level impairment. The PD patients were more depressed than HCs (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), with twice as many (14% vs. 7%) meeting criteria for clinically significant depressive symptoms. The PD patients also experienced more anxiety (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and apathy (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) than HCs. Psychosis was uncommon in PD (3%), and no between\u2010group difference was seen in ICD symptoms (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.51).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Approximately 10% of PD patients in the early, untreated disease state met traditional criteria of CI, which is a lower frequency compared with previous studies. Multiple dopaminergic\u2010dependent NPS are also more common in these patients compared with the general population, but others associated with dopamine replacement therapy are not or are rare. Future analyses of this cohort will examine biological predictors and the course of CI and NPS. \u00a9 2015 International Parkinson and Movement Disorder Society<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.26170","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T05:50:55Z","timestamp":1425448255000},"page":"919-927","source":"Crossref","is-referenced-by-count":300,"title":["Cognitive performance and neuropsychiatric symptoms in early, untreated Parkinson's disease"],"prefix":"10.1002","volume":"30","author":[{"given":"Daniel","family":"Weintraub","sequence":"first","affiliation":[{"name":"Departments of Psychiatry and Neurology Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania USA; Philadelphia Veterans Affairs Medical Center Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Simuni","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea","family":"Caspell\u2010Garcia","sequence":"additional","affiliation":[{"name":"Department of Biostatistics College of Public Health University of Iowa Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Coffey","sequence":"additional","affiliation":[{"name":"Department of Biostatistics College of Public Health University of Iowa Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley","family":"Lasch","sequence":"additional","affiliation":[{"name":"Institute for Neurodegenerative Disorders (IND) and Molecular NeuroImaging LLC (MNI) New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Siderowf","sequence":"additional","affiliation":[{"name":"Avid Radiopharmaceuticals Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dag","family":"Aarsland","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Care Sciences and Society and the Alzheimer Disease Research Centre Karolinska Institutet Stockholm Sweden; Centre for Age\u2010Related Medicine Stavanger University Hospital Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Barone","sequence":"additional","affiliation":[{"name":"Neurodegenerative Diseases Centre Neuroscience Section Department of Medicine University of Salerno  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Burn","sequence":"additional","affiliation":[{"name":"Institute for Ageing and Health Newcastle University Newcastle England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lama M.","family":"Chahine","sequence":"additional","affiliation":[{"name":"Department of Neurology Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Eberling","sequence":"additional","affiliation":[{"name":"Michael J. Fox Foundation for Parkinson's Research New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto J.","family":"Espay","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Cincinnati Academic Health Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Biostatistics College of Public Health University of Iowa Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Leverenz","sequence":"additional","affiliation":[{"name":"Lou Ruvo Center for Brain Health Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Litvan","sequence":"additional","affiliation":[{"name":"UCSD Movement Disorder Center Department of Neurosciences University of California San Diego San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Richard","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Psychiatry University of Rochester School of Medicine and Dentistry Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Troyer","sequence":"additional","affiliation":[{"name":"Medivation Inc. 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